N,N-Bis-(2-chloro-ethyl)-4-chloro-butylamine | 98997-98-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-Bis-(2-chloro-ethyl)-4-chloro-butylamine
• 英文别名: 4-chloro-N,N-bis(2-chloroethyl)butan-1-amine
• CAS: 98997-98-9
• 化学式: C₈H₁₆Cl₃N
• 分子量: 232.581
• InChiKey: HLMNLBXLHAAPQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-Bis-(2-chloro-ethyl)-4-chloro-butylamine 在 双氧水 作用下， 以 乙醚 、 溶剂黄146 为溶剂， 生成 N,N-Bis-(2-chloro-ethyl)-4-chloro-butylamine N-Oxide
  参考文献：
  名称：

  Ishidate,M. et al., Chemical and pharmaceutical bulletin, 1961, vol. 9, p. 485 - 491

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N-Bis-(2-hydroxy-ethyl)-4-amino-butanol-(1) 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 生成 N,N-Bis-(2-chloro-ethyl)-4-chloro-butylamine
  参考文献：
  名称：

  Ishidate,M. et al., Chemical and pharmaceutical bulletin, 1961, vol. 9, p. 485 - 491

  摘要：

  DOI：

文献信息

• STABILIZED COMPOSITIONS OF ALKYLATING AGENTS AND METHODS OF USING SAME
  申请人：Helsinn Healthcare SA

  公开号：EP3494960A1

  公开（公告）日：2019-06-12

  A composition for use in a method of treatment. The composition for use in treating a skin disorder, comprising an alkylating agent which is mechlorethamine hydrochloride, wherein the alkylating agent is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol. The method comprises topically applying the composition of the alkylating agent to the affected skin, wherein the alkylating agent is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol.

  一种用于治疗方法的组合物。该组合物用于治疗皮肤病，包含一种烷化剂，即盐酸甲氯雷他敏，其中烷化剂在不包括凡士林油或乙醇的非水载体或载体中。该方法包括将烷基化剂组合物局部涂抹到受影响的皮肤上，其中烷基化剂在不包括凡士林油或乙醇的非水性载体中。
• METHODS FOR TREATING SKIN DISORDERS WITH TOPICAL NITROGEN MUSTARD COMPOSITIONS
  申请人：Alonso Robert

  公开号：US20110039943A1

  公开（公告）日：2011-02-17

  Provided are methods for treating skin disorders comprising topically applying to the affected skin a composition comprising a nitrogen mustard or a pharmaceutically acceptable salt thereof.
• COMPOSITIONS OF ALKYLATING AGENTS AND METHODS OF TREATING SKIN DISORDERS THEREWITH
  申请人：Alonso Robert

  公开号：US20130184243A1

  公开（公告）日：2013-07-18

  Provided are compositions comprising alkylating agents, including nitrogen mustards, that are suitable for topical use, and methods for treating skin disorders comprising topically administering the compositions.
• Stabilized Compositions Of Alkylating Agents And Methods Of Using Same
  申请人：Actelion Pharmaceuticals, Ltd.

  公开号：US20140142193A1

  公开（公告）日：2014-05-22

  A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: an alkylating agent such as, for example, a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the alkylating agent is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of the alkylating agent to the affected skin, wherein the alkylating agent is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.
• US8501817B2
  申请人：——

  公开号：US8501817B2

  公开（公告）日：2013-08-06