phenyl 2-[(2R)-butan-2-yl]-7-(dimethylamino)-6-methyl-4-[(2-methylpropan-2-yl)oxycarbonyloxy]-1,3-dihydroisoindole-5-carboxylate | 1335556-34-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: phenyl 2-[(2R)-butan-2-yl]-7-(dimethylamino)-6-methyl-4-[(2-methylpropan-2-yl)oxycarbonyloxy]-1,3-dihydroisoindole-5-carboxylate
• CAS: 1335556-34-7
• 化学式: C₂₇H₃₆N₂O₅
• 分子量: 468.593
• InChiKey: OYXGSRGLXXMQSO-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• POLYCYCLIC TETRACYCLINE COMPOUNDS
  申请人：Tetraphase Pharmaceuticals, Inc.

  公开号：EP2552890B1

  公开（公告）日：2017-01-04
• Polycyclic Tetracycline Compounds
  申请人：Xiao Xiao-Yi

  公开号：US20110269714A1

  公开（公告）日：2011-11-03

  The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
• US9371283B2
  申请人：——

  公开号：US9371283B2

  公开（公告）日：2016-06-21
• [EN] POLYCYCLIC TETRACYCLINE COMPOUNDS<br/>[FR] COMPOSÉS POLYCYCLIQUES DE TÉTRACYCLINE
  申请人：TETRAPHASE PHARMACEUTICALS INC

  公开号：WO2011123536A1

  公开（公告）日：2011-10-06

  The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.