N-[cis-3-[(4-chlorophenyl)sulfonyl]-3-(2-cyano-5-fluorophenyl)cyclobutyl]-1,1,1-trifluoromethanesulfonamide | 1192731-80-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[cis-3-[(4-chlorophenyl)sulfonyl]-3-(2-cyano-5-fluorophenyl)cyclobutyl]-1,1,1-trifluoromethanesulfonamide
• CAS: 1192731-80-8
• 化学式: C₁₈H₁₃ClF₄N₂O₄S₂
• 分子量: 496.891
• InChiKey: LWNKIJSAYMHKSY-KDYLLFBJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.62
• 重原子数：
  31.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  104.1
• 氢给体数：
  1.0
• 氢受体数：
  5.0

文献信息

• EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：EP3212773A1

  公开（公告）日：2017-09-06
• TREATMENT OF HEARING LOSS
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：EP3743057A1

  公开（公告）日：2020-12-02
• [EN] EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR<br/>[FR] ADMINISTRATION EFFICACE DE MOLÉCULES THÉRAPEUTIQUES EN DIRECTION DE CELLULES DE L'OREILLE INTERNE
  申请人：MASSACHUSETTS EYE & EAR INFIRM

  公开号：WO2016069906A1

  公开（公告）日：2016-05-06

  Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by administration of a composition which activates the Myc and Notch. Supporting cells are induced to transdifferentiate to hair cells by inhibition of Myc and Notch activity or the activation of Atoh1. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.
• [EN] TREATMENT OF HEARING LOSS<br/>[FR] TRAITEMENT DE LA PERTE AUDITIVE
  申请人：MASSACHUSETTS EYE & EAR INFIRMARY

  公开号：WO2019148067A1

  公开（公告）日：2019-08-01

  Compositions for regeneration of inner cells and for treating hearing loss comprise at least one modulator of mechanistic target of rapamycin (mTOR) sufficient to induce reprogramming proliferation and regeneration of inner ear cells. The composition include, in some instances, an effective amount of one or more phosphatase and tensin homolog (PTEN) inhibitors, MYC/NOTCH modulators, Atonal Homolog 1 (Atohl) modulators or combinations thereof.