3-(2-chloro-phenyl)-2-phenyl-2,3-dihydro-1H-quinazolin-4-one | 21878-32-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(2-chloro-phenyl)-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
• 英文别名: 3-(2-chloro-phenyl)-2-phenyl-2,3-dihydro-1H-quinazolin-4-one；4-Oxo-3-(2-chlor-phenyl)-2-phenyl-1,2,3,4-tetrahydro-chinazolin
• CAS: 21878-32-0
• 化学式: C₂₀H₁₅ClN₂O
• 分子量: 334.805
• InChiKey: OVUUJIKDFPSEQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.11
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  32.34
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  邻氨基苯甲酸 在 copper diacetate 、 palladium diacetate 、 溶剂黄146 、 potassium iodide 作用下， 以 乙腈 为溶剂， 反应 9.0h， 生成 3-(2-chloro-phenyl)-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
  参考文献：
  名称：

  Pd(II)-Catalyzed Cascade Annulation of o-Aminobenzoic Acids with CO, Amines, and Aldehydes to N3-/N1,N3-Substituted 2,3-Dihydroquinazolin-4(1H)-ones

  摘要：

  DOI：

  10.1021/acs.joc.3c00802

文献信息

• Synthesis of 2,3-Dihydroquinazolin-4(1<i>H</i>)-ones by Three-Component Coupling of Isatoic Anhydride, Amines, and Aldehydes Catalyzed by Magnetic Fe₃O₄ Nanoparticles in Water
  作者：Zhan-Hui Zhang、Hong-Yan Lü、Shu-Hong Yang、Jian-Wu Gao

  DOI：10.1021/cc100047j

  日期：2010.9.13

  A simple and efficient protocol for one-pot three-component coupling of isatoic anhydride, amines, and aldehydes in water using magnetically recoverable Fe3O4 nanoparticles is reported. This methodology results in the synthesis of a variety of 2,3-dihydroquinazolin-4(1H)-ones in high yields. The catalyst can be recovered and recycled without a significant loss in the catalytic activity.
• Nano-indium oxide: An efficient catalyst for one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones with a greener prospect
  作者：Sougata Santra、Matiur Rahman、Anupam Roy、Adinath Majee、Alakananda Hajra

  DOI：10.1016/j.catcom.2014.01.032

  日期：2014.4

  Nano-In2O3 is found to be a remarkable efficient catalyst for the one-pot three-component condensation of isatoic anhydride, primary amine or ammonium salts and aromatic aldehydes for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in aqueous media. In2O3 nanoparticles are easily recyclable without the significant loss of catalytic activities. (C) 2014 Elsevier B.V. All rights reserved.