<2-Carboxy-phenyl>-malonsaeure-monoaethylester | 4221-38-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: <2-Carboxy-phenyl>-malonsaeure-monoaethylester
• 英文别名: 2-(1-Carboxy-2-ethoxy-2-oxoethyl)benzoic acid
• CAS: 4221-38-9
• 化学式: C₁₂H₁₂O₆
• 分子量: 252.224
• InChiKey: DDIQZPGHLYOQCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0365324A1

  公开（公告）日：1990-04-25

  This invention relates to spiro-isoquinoline-­pyrrolidine tetrones and pharmaceutically acceptable salts thereof having formula I: and analogues thereof wherein the fused benzene ring is replaced by a fused thiophene, pyridine or furan ring, wherein R¹ , R² and R³ are independently hydrogen or defined substituents and M, W, X, Y and Z have defined meanings. Processes for preparing the compounds and pharmaceutical compositions are also provided. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.

  本发明涉及具有式 I 的螺-异喹啉-吡咯烷四元化合物及其药学上可接受的盐类： 及其类似物，其中融合的苯环被融合的噻吩环、吡啶环或呋喃环取代，其中R¹、R²和R³独立地为氢或定义的取代基，M、W、X、Y和Z具有定义的含义。此外，还提供了制备这些化合物和药物组合物的工艺。 这些化合物具有药物特性，使其有利于预防或治疗糖尿病相关并发症。
• N-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0458549A1

  公开（公告）日：1991-11-27

  This invention relates to N′-alkyl-spiro-isoquinoline-pyrrolidine tetrones of formula wherein R¹ and R² are independently hydrogen, alkyl containing to 1 to 6 carbon atoms, halogen, lower alkoxy containing 1 to 6 carbon atoms, trifluoromethyl, nitro, aryl or aryl(lower alkyl)oxy wherein aryl contains 6 - 10 carbon atoms and lower alkyl contains 1 to 6 carbon atoms; R³ is hydrogen, lower alkyl containing 1 to 6 carbon atoms, aryl, aryl(lower alkyl) or halogen substituted aryl(lower alkyl) wherein aryl contains 6 to 10 carbon atoms and lower alkyl contains 1 to 6 carbon atoms, or benzothiazole of structural formula wherein R⁵ is hydrogen, halogen, alkyl containing 1 to 6 carbon atoms, lower alkoxy containing 1 to 6 carbon atoms, trifluoromethyl, nitro, aryl or aryl(lower alkyl)oxy wherein aryl contains 6 to 10 carbon atoms and lower alkyl contains 1 to 5 carbon atoms; and R⁴ is alkyl containing 1 to 12 carbon atoms, aryl, aryl(loweralkyl) wherein aryl contains 6 to 10 carbon atoms and lower alkyl contains 1 to 6 carbon atoms, acyl, carboalkoxy, -(CH₂)nCO₂H or -(CH₂)nOH, wherein n is 1 to 6. The compounds have pharmaceutical properties which render them beneficial for the prevention of treatment of diabetes mellitus associated complications.

  本发明涉及 N′-烷基-螺-异喹啉-吡咯烷四元化合物，其式为 其中R¹和R²独立地为氢、含1-6个碳原子的烷基、卤素、含1-6个碳原子的低级烷氧基、三氟甲基、硝基、芳基或芳基（低级烷基）氧基，其中芳基含6-10个碳原子，低级烷基含1-6个碳原子；R³ 是氢、含 1 至 6 个碳原子的低级烷基、芳基、芳基（低级烷基）或卤素取代的芳基（低级烷基）（其中芳基含 6 至 10 个碳原子，低级烷基含 1 至 6 个碳原子），或结构式为苯并噻唑 其中 R⁵ 是氢、卤素、含 1 至 6 个碳原子的烷基、含 1 至 6 个碳原子的低级烷氧基、三氟甲基、硝基、芳基或芳基（低级烷基）氧基，其中芳基含 6 至 10 个碳原子，低级烷基含 1 至 5 个碳原子；R⁴是含 1 至 12 个碳原子的烷基、芳基、芳基（低级烷基）（其中芳基含 6 至 10 个碳原子，低级烷基含 1 至 6 个碳原子）、酰基、羧基、-(CH₂)nCO₂H 或-(CH₂)nOH，其中 n 为 1 至 6。这些化合物具有药物特性，有利于预防和治疗糖尿病相关并发症。
• Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0458551B1

  公开（公告）日：1997-12-03
• Process and intermediate for making isoquinoline derivatives
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0519600B1

  公开（公告）日：1997-06-11
• ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO-[ISOQUINOLINE- 4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0555327B1

  公开（公告）日：1999-01-13