N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-[4-hydroxy-1-methyl-2-(4-nitro-benzoylsulfanyl)-but-1-enyl]-formamide | 13521-90-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-[4-hydroxy-1-methyl-2-(4-nitro-benzoylsulfanyl)-but-1-enyl]-formamide
• 英文别名: N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-[4-hydroxy-1-methyl-2-(4-nitro-benzoylsulfanyl)-but-1-enyl]-formamide；N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-[4-hydroxy-1-methyl-2-(4-nitro-benzoylmercapto)-but-1-en-t-yl]-formamide；N-(4-Amino-2-methyl-pyrimidin-5-ylmethyl)-N-[4-hydroxy-1-methyl-2-(4-nitro-benzoylmercapto)-but-1-en-t-yl]-formamid；S-(p-Nitro-benzoyl)-thiamin
• CAS: 13521-90-9
• 化学式: C₁₉H₂₁N₅O₅S
• 分子量: 431.472
• InChiKey: RAZFLLWMESWZIK-ATVHPVEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.42
• 重原子数：
  30.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  152.55
• 氢给体数：
  2.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-[4-hydroxy-1-methyl-2-(4-nitro-benzoylsulfanyl)-but-1-enyl]-formamide 在 乙醇 作用下， 生成 O-(4-nitrobenzoyl)thiamine chloride hydrochloride
  参考文献：
  名称：

  Yoshida, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1954, vol. 74, p. 993,994

  摘要：

  DOI：
• 作为产物：
  描述：

  盐酸硫胺 在 sodium hydroxide 、 水 作用下， 生成 N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-[4-hydroxy-1-methyl-2-(4-nitro-benzoylsulfanyl)-but-1-enyl]-formamide
  参考文献：
  名称：

  A Comparison of Characteristics of Kevorkian Euthanasia Cases and Physician-Assisted Suicides in Oregon

  摘要：

  目的：本研究比较了凯沃尔基安安乐死案例的社会人口学和临床特征，以及俄勒冈州医生协助自杀（PAS）案例和美国死亡数据。设计和方法：从奥克兰县法医对所有69名凯沃尔基安安乐死案例的死亡和尸检报告中编码了200个变量。关于前两年43例俄勒冈州PAS案例和美国死亡数据的信息来源于已发表的资料。结果：只有25%的凯沃尔基安安乐死患者是终末期疾病，相比之下，俄勒冈州PAS案例中这一比例为100%。PAS案例中患有癌症的比例（72%）显著高于安乐死案例（29%）。女性的离婚或从未结婚者寻求安乐死的可能性显著高于全国死亡统计数据的预测。意义：性别和婚姻状况似乎影响了寻求协助死亡的决定，因而研究这些因素在临终决策中的作用是值得的。

  DOI：

  10.1093/geront/41.4.439

文献信息

• US2752348
  申请人：——

  公开号：——

  公开（公告）日：——
• Gene Expression of Cyclooxygenase in the Aging Heart
  作者：J. W. Kim、B. S. Baek、Y. K. Kim、J. T. Herlihy、Y. Ikeno、B. P. Yu、H. Y. Chung

  DOI：10.1093/gerona/56.8.b350

  日期：2001.8.1

  Cyclooxygenase (COX) is the key rate-limiting enzyme in the prostaglandin synthetic pathway. Two isoforms of COX have been identified: a constitutive COX-1 and an inducible COX-2, which is activated in response to various stimuli. We investigated the changes of COX-1 and COX-2 in rat heart during aging. We measured the age-related changes in the mRNA and protein levels of COX by using reverse-transcription polymerase chain reaction and Western blotting, respectively. COX-2 mRNA and protein levels increased with age, whereas those of COX-1 showed no change. The COX activity determined by prostaglandin E-2 production increased with age. Because the COX-catalyzed arachidonate cascade is an important source of reactive oxygen species (ROS) generation, changes in ROS generation and lipid peroxidation were also assessed. The amount of ROS generated by the COX pathway increased with age, as did the total ROS generation and lipid peroxidation. These results show that COX-2 activity increases with age, partially because of elevated transcriptional expression and protein content, and they suggest that increased COX-2 can play a role in oxidative alterations in the aged heart.
• DE929551
  申请人：——

  公开号：——

  公开（公告）日：——
• Kawasaki, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1954, vol. 74, p. 1189,1191
  作者：Kawasaki

  DOI：——

  日期：——