2-[(Z)-1-(4-aminophenyl)ethylidene]-N,N-diprop-2-enylhydrazine-1-carbothioamide | 1310677-52-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(Z)-1-(4-aminophenyl)ethylidene]-N,N-diprop-2-enylhydrazine-1-carbothioamide
• 英文别名: 3-[(Z)-1-(4-aminophenyl)ethylideneamino]-1,1-bis(prop-2-enyl)thiourea
• CAS: 1310677-52-1
• 化学式: C₁₅H₂₀N₄S
• 分子量: 288.417
• InChiKey: ZJLHUEBUUJXBBE-ATVHPVEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  85.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-Amino-1,1-bis(prop-2-enyl)thiourea 在 盐酸 、 sodium acetate 作用下， 以 甲醇 、 水 为溶剂， 反应 0.5h， 生成 2-[(Z)-1-(4-aminophenyl)ethylidene]-N,N-diprop-2-enylhydrazine-1-carbothioamide
  参考文献：
  名称：

  Novel antitubercular diallyl/dibenzylthiosemicarbazones endowed with high activity toward multi-drug-resistant tuberculosis

  摘要：

  Novel diallyl and dibenzylthiosemicarbazones were prepared by three-step reactions. The compounds were tested for their in vitro activity against Mycobacterium tuberculosis H37Rv (MTB) and multi-drug-resistant Mycobacterium tuberculosis (MDR-TB). Most of the compounds showed excellent activity toward MDR-TB. Among the thirty compounds (4,5a-o) tested N,N-dibenzyl-2-((5-nitrofuran-2-yl)methylene)hydrazinecarbothioamide (5g) was found to be the most potent compound MICs of 0.55 and 0.12 mu M against MTB and MDR-TB.

  DOI：

  10.1007/s00044-011-9638-9

文献信息

• Novel antitubercular diallyl/dibenzylthiosemicarbazones endowed with high activity toward multi-drug-resistant tuberculosis
  作者：Dharmarajan Sriram、Debjani Banerjee、Tara Sasank Thripuraribhatla Venkat Varuna、Manikandaprabu Sankar、Perumal Yogeeswari

  DOI：10.1007/s00044-011-9638-9

  日期：2012.6

  Novel diallyl and dibenzylthiosemicarbazones were prepared by three-step reactions. The compounds were tested for their in vitro activity against Mycobacterium tuberculosis H37Rv (MTB) and multi-drug-resistant Mycobacterium tuberculosis (MDR-TB). Most of the compounds showed excellent activity toward MDR-TB. Among the thirty compounds (4,5a-o) tested N,N-dibenzyl-2-((5-nitrofuran-2-yl)methylene)hydrazinecarbothioamide (5g) was found to be the most potent compound MICs of 0.55 and 0.12 mu M against MTB and MDR-TB.