(2-cyclohex-2-enyl-phenylsulfanyl)-acetic acid | 100883-58-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (2-cyclohex-2-enyl-phenylsulfanyl)-acetic acid
• 英文别名: (2-Cyclohex-2-enyl-phenylmercapto)-essigsaeure
• CAS: 100883-58-7
• 化学式: C₁₄H₁₆O₂S
• 分子量: 248.346
• InChiKey: CJXLIMAWNSKKKP-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  二苯并噻吩 在 乙醚 、 氨 、 sodium 作用下， 生成 (2-cyclohex-2-enyl-phenylsulfanyl)-acetic acid
  参考文献：
  名称：

  Phase II study of irinotecan and carboplatin for advanced non-small cell lung cancer

  摘要：

  A phase II study was conducted to assess the activity and toxicity of irinotecan (CPT-11) and carboplatin (CBDCA) combination chemotherapy for advanced non-small-cell lung cancer (NSCLC). Eligibility included chemo-naive advanced NSCLC patients with measurable disease and a good performance status. CPT-11 of 50 mg/m(2) was administered as a 90-min intravenous infusion on days 1, 8, and 15. CBDCA dosed to an area under the concentration-time curve of 5 mg min/ml, using Calvert's formula, was administered by 90-min infusion after the CPT-11 infusion on day 1. Treatment was repeated 28 days interval for at least two cycles. Haematopoietic growth factors were not routinely used. From December 1997 to January 1999, 36 patients were entered into the study. The overall response rate was 25.0% (95% confidence interval: 12.1-42.2%). The median survival time and the 1-year survival rate were 10.2 months and 42.2%, respectively. Major toxicity by Japan Clinical Oncology Group criteria was as follows: grade 3-4 neutropenia 76.5%; grade 3 anemia 26.5%; grade 3/4 thrombocytopenia 47.1%; grade 3 nausea/vomiting 36.1%; grade 3-4 diarrhoea 5.9%; grade 3 alopecia 5.9%; grade 3-4 skin rush 2.9%. Four patients developed febrile neutropenia and only one had serious diarrhea induced by CPT-11. Actual relative delivery dose of CPT-11 to the projected one on days 8 and 15 were 0.86 and 0.43, respectively. It seemed that CPT-11 and CBDCA was more toxic regimen than CPT-11 and CDDP in advanced NSCLC. The relatively disappointing response rate could be related with low dose intensity of CPT-11. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

  DOI：

  10.1016/s0169-5002(02)00304-5