dimethyl 1-(1,2,3,4-tetrahydrophenanthren-4-yl)-piperidine-4,4-dicarboxylate | 1581755-22-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: dimethyl 1-(1,2,3,4-tetrahydrophenanthren-4-yl)-piperidine-4,4-dicarboxylate
• CAS: 1581755-22-7
• 化学式: C₂₃H₂₇NO₄
• 分子量: 381.472
• InChiKey: BFNNKARADJLDGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.65
• 重原子数：
  28.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  55.84
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  dimethyl 1-(1,2,3,4-tetrahydrophenanthren-4-yl)-piperidine-4,4-dicarboxylate 在 sodium cyanide 、 氢气 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以67%的产率得到methyl 1-(1,2,3,4-tetrahydrophenanthren-4-yl)piperidine-4-carboxylate
  参考文献：
  名称：

  X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases

  摘要：

  Structure-guided design was used to generate a series of noncovalent inhibitors with nanomolar potency against the papain-like protease (PLpro) from the SARS coronavirus (CoV). A number of inhibitors exhibit antiviral activity against SARS-CoV infected Vero E6 cells and broadened specificity toward the homologous PLP2 enzyme from the human coronavirus NL63. Selectivity and cytotoxicity studies established a more than 100-fold preference for the coronaviral enzyme over homologous human deubiquitinating enzymes (DUBs), and no significant cytotoxicity in Vero E6 and HEK293 cell lines is observed. X-ray structural analyses of inhibitor-bound crystal structures revealed subtle differences between binding modes of the initial benzodioxolane lead (15g) and the most potent analogues 3k and 3j, featuring a monofluoro substitution at para and meta positions of the benzyl ring, respectively. Finally, the less lipophilic bis(amide) 3e and methoxypyridine 5c exhibit significantly improved metabolic stability and are viable candidates for advancing to in vivo studies.

  DOI：

  10.1021/jm401712t
• 作为产物：
  描述：

  dimethyl 1-(1,2,3,4-tetrahydrophenanthren-4-yl)pyridine-4,4(1H)-dicarboxylate 在 platinum(IV) oxide 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 5.0h， 以67%的产率得到dimethyl 1-(1,2,3,4-tetrahydrophenanthren-4-yl)-piperidine-4,4-dicarboxylate
  参考文献：
  名称：

  X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases

  摘要：

  Structure-guided design was used to generate a series of noncovalent inhibitors with nanomolar potency against the papain-like protease (PLpro) from the SARS coronavirus (CoV). A number of inhibitors exhibit antiviral activity against SARS-CoV infected Vero E6 cells and broadened specificity toward the homologous PLP2 enzyme from the human coronavirus NL63. Selectivity and cytotoxicity studies established a more than 100-fold preference for the coronaviral enzyme over homologous human deubiquitinating enzymes (DUBs), and no significant cytotoxicity in Vero E6 and HEK293 cell lines is observed. X-ray structural analyses of inhibitor-bound crystal structures revealed subtle differences between binding modes of the initial benzodioxolane lead (15g) and the most potent analogues 3k and 3j, featuring a monofluoro substitution at para and meta positions of the benzyl ring, respectively. Finally, the less lipophilic bis(amide) 3e and methoxypyridine 5c exhibit significantly improved metabolic stability and are viable candidates for advancing to in vivo studies.

  DOI：

  10.1021/jm401712t