Methyl 5-amino-6-bromonicotinate | 1379369-63-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Methyl 5-amino-6-bromonicotinate
• 英文别名: methyl 5-amino-6-bromopyridine-3-carboxylate
• CAS: 1379369-63-7
• 化学式: C₇H₇BrN₂O₂
• 分子量: 231.05
• InChiKey: IKKSIKVBKBKPBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  65.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS<br/>[FR] COMPOSÉS POLYHÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE METTL3
  申请人：STORM THERAPEUTICS LTD

  公开号：WO2021111124A1

  公开（公告）日：2021-06-10

  The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X-Y-Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

  本发明涉及具有以下式（I）的化合物，其作为METTL3（N6-腺苷-甲基转移酶70kDa亚基）酶活性的抑制剂：X-Y-Z（I），其中X、Y和Z如本文所定义。本发明还涉及制备这些化合物的方法，包括含有它们的药物组合物，以及它们在治疗增生性疾病（如癌症）、自身免疫疾病以及METTL3活性相关的其他疾病或病况中的用途。
• NITROGEN-CONTAINING HETEROARYL COMPOUND AND PHARMACEUTICAL USE THEREOF
  申请人：JAPAN TOBACCO INC.

  公开号：US20190152926A1

  公开（公告）日：2019-05-23

  The invention provides a compound having a GLUT9 inhibitory activity. The compound is of Formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.

  该发明提供了一种具有GLUT9抑制活性的化合物。该化合物的化学式为[I]，其中每个符号如规范中所定义，或其药用可接受的盐。
• NITROGEN-CONTAINING HETEROARYL COMPOUND, AND PHARMACEUTICAL USE THEREOF
  申请人：Japan Tobacco Inc.

  公开号：EP3693358A1

  公开（公告）日：2020-08-12

  The present invention provides a compound having a GLUT9 inhibitory activity. The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof. wherein each symbol is as defined in the specification.

  本发明提供了一种具有 GLUT9 抑制活性的化合物。 本发明提供了一种式[I]化合物或其药学上可接受的盐。 其中各符号如说明书中所定义。
• Nitrogen-containing heteroaryl compound and pharmaceutical use thereof
  申请人：JAPAN TOBACCO INC.

  公开号：US10752596B2

  公开（公告）日：2020-08-25

  The invention provides a compound having a GLUT9 inhibitory activity. The compound is of Formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有 GLUT9 抑制活性的化合物。该化合物如式[I]所示 其中各符号如说明书中所定义，或其药学上可接受的盐。
• TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP3122346A2

  公开（公告）日：2017-02-01