N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide | 694482-09-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide
• 英文别名: N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide
• CAS: 694482-09-2
• 化学式: C₂₃H₁₉F₃N₂O₄
• 分子量: 444.41
• InChiKey: WMFCVZIUILKWJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Compound and method for the treatment of pain
  申请人：——

  公开号：US20030149042A1

  公开（公告）日：2003-08-07

  A compound, 7-chloro-4-hydroxy-2-(2-chloro-4-methylphenyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administration of a pain-ameliorating effective amount of the compound and pharmaceutical compositions containing the compound are disclosed.

  本文披露了一种化合物，即7-氯-4-羟基-2-(2-氯-4-甲基苯基)-1,2,5,10-四氢吡啶并[4,5-b]喹啉-1,10-二酮，其药用可接受的盐，一种治疗疼痛的方法，包括给予该化合物的疼痛缓解有效量，并含有该化合物的药物组合物。
• 1, 2, 5, 10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain
  申请人：——

  公开号：US20040053929A1

  公开（公告）日：2004-03-18

  Compounds according to structural diagram (I) are disclosed, wherein R 1 , A, E and D are as defined in the specification. Also disclosed are pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram (I).

  本发明揭示了根据结构图(I)的化合物，其中R1、A、E和D如规范中所定义。还揭示了包含符合结构图(I)的化合物的缓解疼痛有效量的药物组合物。
• 7-Chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain
  申请人：——

  公开号：US20040053930A1

  公开（公告）日：2004-03-18

  A compound, 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b] quinoline-1,10-dione, its (−) enantiomer, its (+) enantiomer, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administering a pain-ameliorating effective amount of the (−) enantiomer to an individual suffering from pain and pharmaceutical compositions containing the (−) enantiomer are disclosed.

  本发明涉及一种化合物，即7-氯-4-羟基-2-(2-吡啶基乙基)-1,2,5,10-四氢吡啶并[4,5-b]喹啉-1,10-二酮，其(−)对映体，其(+)对映体，其药学上可接受的盐，一种治疗疼痛的方法，包括向遭受疼痛的个体投与(−)对映体的止痛有效量，以及含有(−)对映体的制药组合物。
• [EN] 7-CHLORO-4-HYDROXY-2-(2-PYRIDYLETHYL)-1,2,5,10-TETRAHYDROPYRIDAZINO[4,5-B]QUINOLINE-1,10-DIONE AND THE USE THEREOF FOR THE TREATMENT OF PAIN<br/>[FR] 7-CHLORO-4-HYDROXY-2-(2-PYRIDYLETHYL)-1,2,5,10-TETRAHYDROPYRIDAZINO[4,5-B]QUINOLINE-1,10-DIONE ET SON UTILISATION POUR LE TRAITEMENT DE LA DOULEUR
  申请人：ASTRAZENECA AB

  公开号：WO2002026740A1

  公开（公告）日：2002-04-04

  A compound, 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b] quinoline-1,10-dione, its (-) enantiomer, its (+) enantiomer, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administering a pain-ameliorating effective amount of the (-) enantiomer to an individual suffering from pain and pharmaceutical compositions containing the (-) enantiomer are disclosed.

  本发明公开了一种化合物，即7-氯-4-羟基-2-(2-吡啶乙基)-1,2,5,10-四氢吡啶并[4,5-b]喹啉-1,10-二酮，其(-)对映体，其(+)对映体，其药学上可接受的盐，以及一种治疗疼痛的方法，包括向正在经历疼痛的个体投与有效减轻疼痛的量的(-)对映体，以及含有(-)对映体的制药组合物。
• Compounds and methods for the treatment of pain
  申请人：Brown Gordon Dean

  公开号：US20050124622A1

  公开（公告）日：2005-06-09

  2-substituted 7-chloro-4-hydroxy-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione compounds, pharmaceutical compositions and methods for the treatment of pain are disclosed.

  本发明公开了2-取代的7-氯-4-羟基-1,2,5,10-四氢吡啶并[4,5-b]喹啉-1,10-二酮化合物、药物组合物和用于治疗疼痛的方法。