2-(4-(biphenyl-4-yl)thiazole-2-yl)guanidine hydrochloride | 188611-65-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-(biphenyl-4-yl)thiazole-2-yl)guanidine hydrochloride
• 英文别名: 2-[4-(4-Phenylphenyl)-1,3-thiazol-2-yl]guanidine;hydrochloride
• CAS: 188611-65-6
• 化学式: C₁₆H₁₄N₄S*ClH
• 分子量: 330.841
• InChiKey: SIIMEFJQNXYCAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• NOVEL THIAZOLE-BASED COMPOUND AND INHIBITOR OF T-TYPE CALCIUM CHANNEL CONTAINING THE SAME
  申请人：Hahn Hoh-Gyu

  公开号：US20100179201A1

  公开（公告）日：2010-07-15

  The present invention relates to novel thiazole-based compounds and T-type calcium channel inhibitors containing the compound. The T-type calcium channel inhibitor of the present invention is useful as a treating agent for disease associated with overexpression of T-type calcium channel.
• US8143296B2
  申请人：——

  公开号：US8143296B2

  公开（公告）日：2012-03-27
• [EN] NOVEL THIAZOLE-BASED COMPOUND AND INHIBITOR OF T-TYPE CALCIUM CHANNEL CONTAINING THE SAME<br/>[FR] NOUVEAU COMPOSÉ À BASE DE THIAZOLE ET INHIBITEUR DE CANAUX CALCIQUES DE TYPE T LE CONTENANT
  申请人：KOREA INST SCI & TECH

  公开号：WO2008018655A1

  公开（公告）日：2008-02-14

  [EN] The present invention relates to novel thiazole-based compounds and T- type calcium channel inhibitors containing the compound. The T-type calcium channel inhibitor of the present invention is useful as a treating agent for disease associated with overexpression of T-type calcium channel.
  [FR] La présente invention concerne de nouveaux composés à base de thiazole et des inhibiteurs de canaux calciques de type T contenant le composé. L'inhibiteur de canaux calciques de type T de la présente invention peut servir d'agent de traitement d'une maladie associée à la surexpression des canaux calciques de type T.