Fmoc-Val-(Z)Ala-OH | 952226-19-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-Val-(Z)Ala-OH
• 英文别名: (2S)-2-[[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]-phenylmethoxycarbonylamino]propanoic acid
• CAS: 952226-19-6
• 化学式: C₃₁H₃₃N₃O₇
• 分子量: 559.619
• InChiKey: KOXDPVLEOBTSNA-DCFHFQCYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Fmoc-Val-(Z)Ala-OH 、 Fmoc-L-脯氨酸 、 Fmoc-L-苯丙氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 以46%的产率得到PFVh(Z)AL
  参考文献：
  名称：

  Solid-phase synthesis of hydrazinopeptides in Boc and Fmoc strategies monitored by HR-MAS NMR

  摘要：

  With the aim of finding good conditions to incorporate hydrazino moieties into peptidic sequences of biological interest, we developed two strategies towards solid-phase synthesis of hydrazinopeptides: a stepwise methodology in which a hydrazinoacid was introduced as a normal aminoacid and a semi-convergent one in which the hydrazino moiety is incorporated as a pseudodipeptide building block. HR-MAS NMR analyses were run in order to monitor the reaction and to improve the reaction conditions. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.07.038
• 作为产物：
  描述：

  在 sodium hydroxide 、 碳酸氢钠 、 calcium chloride 作用下， 以 二氯甲烷 、 水 、 异丙醇 为溶剂， 生成 Fmoc-Val-(Z)Ala-OH
  参考文献：
  名称：

  Solid-phase synthesis of hydrazinopeptides in Boc and Fmoc strategies monitored by HR-MAS NMR

  摘要：

  With the aim of finding good conditions to incorporate hydrazino moieties into peptidic sequences of biological interest, we developed two strategies towards solid-phase synthesis of hydrazinopeptides: a stepwise methodology in which a hydrazinoacid was introduced as a normal aminoacid and a semi-convergent one in which the hydrazino moiety is incorporated as a pseudodipeptide building block. HR-MAS NMR analyses were run in order to monitor the reaction and to improve the reaction conditions. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.07.038