5-Methoxy-1-methyl-4-propan-2-ylnaphthalene | 1050230-15-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-Methoxy-1-methyl-4-propan-2-ylnaphthalene
• CAS: 1050230-15-3
• 化学式: C₁₅H₁₈O
• 分子量: 214.307
• InChiKey: XQKSLBHOKNBAMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-Methoxy-1-methyl-4-propan-2-ylnaphthalene 在 氢溴酸 、 溶剂黄146 作用下， 反应 1.0h， 以91%的产率得到8-异丙基-5-甲基萘-1-醇
  参考文献：
  名称：

  Total Synthesis of (±)- Cis -5-Hydroxycalamenene

  摘要：

  A total synthesis of (+/-)-cis-5-hydroxycalamenene 1 has been achieved from tetralone 5, which in turn was prepared from 5-methoxy-alpha-tetralone 3. Grignard reaction of compound 5 with isopropylmagnesium chloride, followed by dehydration and aromatization, provided the substituted naphthalene 7 whose conversion to (+/-)-cis-5-hydroxycalamenene 1 was accomplished by demethylation, formylation, and hydrogenation.

  DOI：

  10.1080/00397910802026204
• 作为产物：
  描述：

  1,2-dihydro-4-isopropyl-5-methoxy-1-methylnaphthalene 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 以75%的产率得到5-Methoxy-1-methyl-4-propan-2-ylnaphthalene
  参考文献：
  名称：

  Total Synthesis of (±)- Cis -5-Hydroxycalamenene

  摘要：

  A total synthesis of (+/-)-cis-5-hydroxycalamenene 1 has been achieved from tetralone 5, which in turn was prepared from 5-methoxy-alpha-tetralone 3. Grignard reaction of compound 5 with isopropylmagnesium chloride, followed by dehydration and aromatization, provided the substituted naphthalene 7 whose conversion to (+/-)-cis-5-hydroxycalamenene 1 was accomplished by demethylation, formylation, and hydrogenation.

  DOI：

  10.1080/00397910802026204

文献信息

• Total Synthesis of (±)-<b> <i>Cis</i> </b>-5-Hydroxycalamenene
  作者：Po S. Poon Ng、Ajoy K. Banerjee

  DOI：10.1080/00397910802026204

  日期：2008.6.20

  A total synthesis of (+/-)-cis-5-hydroxycalamenene 1 has been achieved from tetralone 5, which in turn was prepared from 5-methoxy-alpha-tetralone 3. Grignard reaction of compound 5 with isopropylmagnesium chloride, followed by dehydration and aromatization, provided the substituted naphthalene 7 whose conversion to (+/-)-cis-5-hydroxycalamenene 1 was accomplished by demethylation, formylation, and hydrogenation.