5,7-diacetamido-8-acetoxy-2-methyl-quinazoline | 1226498-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5,7-diacetamido-8-acetoxy-2-methyl-quinazoline
• CAS: 1226498-73-2
• 化学式: C₁₅H₁₆N₄O₄
• 分子量: 316.316
• InChiKey: LRMCYMFUKZJFHF-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  5,7-diacetamido-8-acetoxy-2-methyl-quinazoline 在 potassium dichromate 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 1.5h， 以80%的产率得到7-acetamido-2-methyl-quinazoline-5,8-dione
  参考文献：
  名称：

  Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones

  摘要：

  A group of styrylazanaphthalenes and azanaphthalenediones were synthesized and tested for their anti-proliferative activity. Most of the compounds were obtained with the use of microwave-assisted synthesis. The lipophilicity of the compounds was measured by RP-HPLC and their anti-proliferative activity was assayed against the human SK-N-MC neuroepithelioma and HCT116 human colon carcinoma cell lines. Active compounds were also tested in clonogenity and comet assays. Several quinazolinone and styrylquinazoline analogues were found to have markedly greater anti-proliferative activity than desferoxamine and cis-platin. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.02.025
• 作为产物：
  描述：

  、 乙酸酐 在 sodium acetate 、 sodium sulfite 作用下， 反应 1.5h， 以50%的产率得到5,7-diacetamido-8-acetoxy-2-methyl-quinazoline
  参考文献：
  名称：

  Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones

  摘要：

  A group of styrylazanaphthalenes and azanaphthalenediones were synthesized and tested for their anti-proliferative activity. Most of the compounds were obtained with the use of microwave-assisted synthesis. The lipophilicity of the compounds was measured by RP-HPLC and their anti-proliferative activity was assayed against the human SK-N-MC neuroepithelioma and HCT116 human colon carcinoma cell lines. Active compounds were also tested in clonogenity and comet assays. Several quinazolinone and styrylquinazoline analogues were found to have markedly greater anti-proliferative activity than desferoxamine and cis-platin. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.02.025