1-(2,3-dimethoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea | 1342277-66-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,3-dimethoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea
• 英文别名: 1-[(2,3-Dimethoxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea
• CAS: 1342277-66-0
• 化学式: C₁₈H₁₈N₄O₃S
• 分子量: 370.432
• InChiKey: KODIGROAYKMBJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• PYRIDYLTHIAZOLE-BASED UREAS AS INHIBITORS OF RHO ASSOCIATED PROTEIN KINASE (ROCK) AND METHODS OF USE
  申请人：Lawrence Nicholas J.

  公开号：US20130059839A1

  公开（公告）日：2013-03-07

  Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.
• US9221808B2
  申请人：——

  公开号：US9221808B2

  公开（公告）日：2015-12-29
• [EN] PYRIDYLTHIAZOLE-BASED UREAS AS INHIBITORS OF RHO ASSOCIATED PROTEIN KINASE (ROCK) AND METHODS OF USE<br/>[FR] URÉES À BASE DE PYRIDYLTHIAZOLE UTILISÉES COMME INHIBITEURS DES PROTÉINES KINASES ASSOCIÉES À RHO (ROCK), ET LEURS PROCÉDÉS D'UTILISATION
  申请人：H LEE MOFFITT CANCER CT & RES

  公开号：WO2011130740A2

  公开（公告）日：2011-10-20

  Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.