N-ethyl(2,2-dimethyladamant-1-yl)amine | 1404434-81-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethyl(2,2-dimethyladamant-1-yl)amine
• 英文别名: N-benzyl-2,2-dimethyladamantan-1-amine
• CAS: 1404434-81-6
• 化学式: C₁₉H₂₇N
• 分子量: 269.43
• InChiKey: LVZBBDOQXVJIPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-ethyl(2,2-dimethyladamant-1-yl)amine 在 盐酸 、 sodium cyanoborohydride 作用下， 以 乙醚 、 水 、 乙腈 为溶剂， 反应 24.04h， 生成 N-benzyl-N-methyl(2,2-dimethyladamant-1-yl)amine
  参考文献：
  名称：

  Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds

  摘要：

  The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.

  DOI：

  10.1021/ml300279b

文献信息

• Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds
  作者：Eva Torres、Roser Fernández、Stéphanie Miquet、Mercè Font-Bardia、Evelien Vanderlinden、Lieve Naesens、Santiago Vázquez

  DOI：10.1021/ml300279b

  日期：2012.12.13

  The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.