1-Phenyl-4-methyl-4-n-butylpyrazolidin-3,5-dion | 54505-61-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Phenyl-4-methyl-4-n-butylpyrazolidin-3,5-dion
• 英文别名: 4-Butyl-4-methyl-1-phenyl-pyrazolidin-3,5-dion；4-butyl-4-methyl-1-phenyl-pyrazolidine-3,5-dione；4-Butyl-4-methyl-1-phenylpyrazolidine-3,5-dione
• CAS: 54505-61-2
• 化学式: C₁₄H₁₈N₂O₂
• 分子量: 246.309
• InChiKey: WFODWQIMNUVMNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Formulation for fast dissolution of lipophilic compounds
  申请人：Rijksuniversiteit Groningen

  公开号：EP1428526A1

  公开（公告）日：2004-06-16

  The present invention relates to a pharmaceutical composition comprising at least one lipophilic compound and at least one glass of a sugar, a sugar alcohol, a mixture of sugars, a mixture of sugar alcohols or a mixture of at least one sugar and at least one sugar alcohol, wherein the lipophilic compound is incorporated in the sugar glass. The present invention further relates to a method for manufacturing such a pharmaceutical composition.

  本发明涉及一种药物组合物，该组合物包含至少一种亲脂性化合物和至少一种糖、糖醇、糖混合物、糖醇混合物或至少一种糖和至少一种糖醇的混合物玻璃，其中亲脂性化合物掺入糖玻璃中。本发明还涉及一种制造这种药物组合物的方法。
• FORMULATION FOR FAST DISSOLUTION OF LIPOPHILIC COMPOUNDS
  申请人：Rijksuniversiteit Groningen

  公开号：EP1572157A1

  公开（公告）日：2005-09-14
• [EN] FORMULATION FOR FAST DISSOLUTION OF LIPOPHILIC COMPOUNDS<br/>[FR] FORMULATION DESTINEE A UNE DISSOLUTION RAPIDE DE COMPOSES LIPOPHILES
  申请人：UNIV GRONINGEN

  公开号：WO2004054546A1

  公开（公告）日：2004-07-01

  The present invention relates to a pharmaceutical composition comprising at least one lipophilic compound and at least one glass of a sugar, a sugar alcohol, a mixture of sugars, a mixture of sugar alcohols or a mixture of at least one sugar and at least one sugar alcohol, wherein the lipophilic compound is incorporated in the sugar glass. The present invention further relates to a method for manufacturing such a pharmaceutical composition.