N-(5,5-dioxo-5λ⁶-dibenzothiophen-2-yl)-acetamide | 110060-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: N-(5,5-dioxo-5λ⁶-dibenzothiophen-2-yl)-acetamide
• 英文别名: N-(5,5-Dioxo-5λ⁶-dibenzothiophen-2-yl)-acetamid；5,5-dioxo-2-acetamidodibenzothiophene；N-(5,5-Dioxo-5H-5lambda*6*-dibenzothiophen-2-yl)-acetamide；N-(5,5-dioxodibenzothiophen-2-yl)acetamide
• CAS: 110060-36-1
• 化学式: C₁₄H₁₁NO₃S
• 分子量: 273.312
• InChiKey: YNQPZBJSVWSESM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  71.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(5,5-dioxo-5λ⁶-dibenzothiophen-2-yl)-acetamide 、 碘甲烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-(5,5-Dioxo-5H-5λ⁶-dibenzothiophen-2-yl)-N-methyl-acetamide
  参考文献：
  名称：

  Selective Inhibitors of Monoamine Oxidase. 2. Arylamide SAR

  摘要：

  Monoamine oxidase (MAO) exists in two forms distinguishable by substrate specificity. Inhibition of MAO A is believed to be responsible for the antidepressant activity of MAO inhibitors. A group of N-arylacetamides are highly specific inhibitors of MAO A, some with IC50 values in the 10-100 nM range. The requirements for high activity and specificity include a nearly linear tricyclic aromatic portion but a larger and a smaller central ring component. The amide group, which is best acetamido, is optimally placed para to the smaller central group. The size and shape of the aromatic moiety appear to be the major influence on activity and specificity for MAO A.

  DOI：

  10.1021/jm00039a021
• 作为产物：
  描述：

  N-(二苯并噻吩-2-基)乙酰胺 生成 N-(5,5-dioxo-5λ⁶-dibenzothiophen-2-yl)-acetamide
  参考文献：
  名称：

  Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by np y5 receptor

  摘要：

  式(I)的化合物： 其中： X是式(A)或(B)的基团： 而R1、R2、R3、R4、n、x、y和z的定义如所述。 还描述了它们的制备过程以及它们在治疗由神经肽Y5受体介导的疾病中的用途，如在温血动物，如人类中的用途。

  公开号：

  US20030225097A1

文献信息

• Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor
  申请人：Block Howard Michael

  公开号：US20050209233A1

  公开（公告）日：2005-09-22

  Compounds of formula (I): wherein: X is a group of formula (B): and R 1 , R 2 , R 4 , n, x, y and z are as defined within are described. Processes for their preparation and their use in the treatment of disorders mediated by the neuropeptide Y5 receptor in a warm-blooded animal, such as a human being, are also described.

  本文描述了化学式（I）的化合物：其中X是化学式（B）的基团，并且R1、R2、R4、n、x、y和z的定义如所述。还描述了它们的制备过程以及它们在治疗温血动物（如人类）中由神经肽Y5受体介导的疾病中的应用。
• Nitro and Amino Derivatives of Dibenzothiophene
  作者：Robert K. Brown、Norman A. Nelson、J. Charles Wood

  DOI：10.1021/ja01125a009

  日期：1952.3
• AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR
  申请人：AstraZeneca AB

  公开号：EP1278739A1

  公开（公告）日：2003-01-29
• US6967216B2
  申请人：——

  公开号：US6967216B2

  公开（公告）日：2005-11-22
• US7332492B2
  申请人：——

  公开号：US7332492B2

  公开（公告）日：2008-02-19