(N'-phenyl-hydrazino)-malonic acid monoethyl ester | 859201-35-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (N'-phenyl-hydrazino)-malonic acid monoethyl ester
• 英文别名: (N'-Phenyl-hydrazino)-malonsaeure-monoaethylester
• CAS: 859201-35-7
• 化学式: C₁₁H₁₄N₂O₄
• 分子量: 238.243
• InChiKey: KCKXLYLGRDDNHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.62
• 重原子数：
  17.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  87.66
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (N'-phenyl-hydrazino)-malonic acid monoethyl ester 在 水 、 三氯化铁 作用下， 生成 (+/-)-phenylazo-malonic acid monoethyl ester
  参考文献：
  名称：

  Mild renal failure is associated with adverse outcome after cardiac valve surgery

  摘要：

  The present study was performed to ascertain whether the presence of mild renal failure (defined as a serum creatinine concentration of 1.5 to 3.0 mg/dL) is an independent risk factor. for adverse outcome after cardiac valve surgery. An extensive set of preoperative and postoperative data was collected in 834 prospectively evaluated patients undergoing cardiac valve surgery at 14 Veterans Affairs Medical Centers. Univariate and multivariable analyses were performed to determine whether an independent association of mild renal dysfunction with adverse outcomes was present. Patients with mild renal failure had significantly greater do-day mortality rates (P = 0.001; 16% versus 6%) and frequency of postoperative bleeding (P = 0.023; 16% versus 8%), respiratory complications (P = 0.02, 29% versus 16%), and cardiac complications (P = 0.002; 18% versus 7%) than patients with normal renal function (serum creatinine <1.5 mg/dL) when controlling for multiple other variables. The presence of a serum creatinine concentration of 1.5 to 3.0 mg/dL is significantly and independently associated with adverse outcomes after cardiac valve surgery. (C) 2000 by the National Kidney Foundation, Inc.

  DOI：

  10.1016/s0272-6386(00)70050-3
• 作为产物：
  描述：

  2-(苯基肼)丙二酸二乙酯 在 乙酰乙酸乙酯钠 作用下， 生成 (N'-phenyl-hydrazino)-malonic acid monoethyl ester
  参考文献：
  名称：

  Mild renal failure is associated with adverse outcome after cardiac valve surgery

  摘要：

  The present study was performed to ascertain whether the presence of mild renal failure (defined as a serum creatinine concentration of 1.5 to 3.0 mg/dL) is an independent risk factor. for adverse outcome after cardiac valve surgery. An extensive set of preoperative and postoperative data was collected in 834 prospectively evaluated patients undergoing cardiac valve surgery at 14 Veterans Affairs Medical Centers. Univariate and multivariable analyses were performed to determine whether an independent association of mild renal dysfunction with adverse outcomes was present. Patients with mild renal failure had significantly greater do-day mortality rates (P = 0.001; 16% versus 6%) and frequency of postoperative bleeding (P = 0.023; 16% versus 8%), respiratory complications (P = 0.02, 29% versus 16%), and cardiac complications (P = 0.002; 18% versus 7%) than patients with normal renal function (serum creatinine <1.5 mg/dL) when controlling for multiple other variables. The presence of a serum creatinine concentration of 1.5 to 3.0 mg/dL is significantly and independently associated with adverse outcomes after cardiac valve surgery. (C) 2000 by the National Kidney Foundation, Inc.

  DOI：

  10.1016/s0272-6386(00)70050-3