9H-thioxanthene-2,7-dicarbaldehyde | 1176226-58-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻喃类
• 英文名称: 9H-thioxanthene-2,7-dicarbaldehyde
• CAS: 1176226-58-6
• 化学式: C₁₅H₁₀O₂S
• 分子量: 254.309
• InChiKey: QGSPNRDZEVGDEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.37
• 重原子数：
  18.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  34.14
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  9H-thioxanthene-2,7-dicarbaldehyde 、 3,4-diamino-N-isopropylbenzamidine hydrochloride 在 对苯醌 作用下， 以 乙醇 为溶剂， 以75%的产率得到
  参考文献：
  名称：

  Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents

  摘要：

  A series of bis-benzimidazole diamidine compounds containing different central linkers has been synthesized and evaluated for in vitro antibacterial activities, including drug-resistant bacterial strains. Seven compounds have shown potent antibacterial activities. The anti-MRSA and anti-VRE activities of compound 1h were more potent than that of the lead compound 1a and vancomycin. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.061
• 作为产物：
  描述：

  2,7-Dicyanothioxanthene 在 二异丁基氢化铝 作用下， 以 甲苯 为溶剂， 以62%的产率得到9H-thioxanthene-2,7-dicarbaldehyde
  参考文献：
  名称：

  Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents

  摘要：

  A series of bis-benzimidazole diamidine compounds containing different central linkers has been synthesized and evaluated for in vitro antibacterial activities, including drug-resistant bacterial strains. Seven compounds have shown potent antibacterial activities. The anti-MRSA and anti-VRE activities of compound 1h were more potent than that of the lead compound 1a and vancomycin. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.061