1-(4-氨基-3-吡啶基)乙醇 | 741223-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 1-(4-氨基-3-吡啶基)乙醇
• 英文名称: α-methyl-4-amino-3-pyridinylmethanol
• 英文别名: 1-(4-Aminopyridin-3-yl)ethanol
• CAS: 741223-49-4
• 化学式: C₇H₁₀N₂O
• 分子量: 138.169
• InChiKey: GJGHCHUEXGVZKX-UHFFFAOYSA-N

物化性质

• 沸点：
  344.0±27.0 °C(Predicted)
• 密度：
  1.191±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  59.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] NOVEL CRYPTOPHYCIN COMPOUNDS AND CONJUGATES, THEIR PREPARATION AND THEIR THERAPEUTIC USE<br/>[FR] NOUVEAUX COMPOSÉS ET CONJUGUÉS DE CRYPTOPHYCINE, LEUR PRÉPARATION ET LEUR UTILISATION THÉRAPEUTIQUE
  申请人：SANOFI SA

  公开号：WO2017076998A1

  公开（公告）日：2017-05-11

  The present invention relates to cryptophycin compounds of formula (I). The invention also relates to cryptophycin payloads, to cryptophycin conjugates, to compositions containing them and to their therapeutic use, especially as anticancer agents. The invention also relates to the process for preparing these conjugates.

  本发明涉及公式（I）的隐藻素化合物。该发明还涉及隐藻素有效载荷、隐藻素偶联物、含有它们的组合物及其治疗用途，尤其是作为抗癌剂。该发明还涉及制备这些偶联物的过程。
• Aminopyridinylmethanols and aminomethylpyridinamines and related compounds, a process for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0435222A2

  公开（公告）日：1991-07-03

  The present invention relates to various compounds of the formula I, where X is OH, O, NOH, NH₂, loweralkylamino, cycloalkylamino, arylloweralkylamino or arylamino; R₁ is H, loweralkylcarbonyl, arylcarbonyl, arylloweralkylcarbonyl, loweralkyl or arylloweralkyl; R₂ is hydrogen, loweralkyl, cycloalkyl, arylloweralkyl, aryl; and R₃ when present is hydrogen, loweralkyl, cycloalkyl, arylloweralkyl or aryl with the proviso that, if X is OH or NH₂, R₁, R₂ and R₃ may not all be hydrogen; and if X = O, R₂ may not be hydrogen and R₁ may not be 2,2-dimethylpropionyl; and a process for their preparation. The compounds of the invention are useful for the treatment of various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease, as topical antiinflammatory agents for the treatment of various dermatoses and also as analgesic agents.

  本发明涉及式 I 的各种化合物、 其中 X是OH、O、NOH、NH₂、低级烷基氨基、环烷基氨基、芳基低级烷基氨基或芳基氨基 芳基低级烷基氨基或芳基氨基； R₁ 是 H、低级烷基羰基、芳基羰基、芳低级烷基羰基、低级烷基或芳低级烷基； R₂ 是氢、低级烷基、环烷基、芳低级烷基、芳基；R₃ 存在时是氢、低级烷基、环烷基、芳低级烷基或芳基，但如果 X 是 OH 或 NH₂，R₁、R₂ 和 R₃ 不一定都是氢； 如果 X = O，R₂ 可能不是氢，R₁ 可能不是 2,2-二甲基丙酰基； 及其制备工艺。 本发明的化合物可用于治疗以胆碱能不足为特征的各种记忆功能障碍，如阿尔茨海默病，也可用作治疗各种皮肤病的局部消炎剂和镇痛剂。
• Cryptophycin compounds and conjugates, their preparation and their therapeutic use
  申请人：SANOFI

  公开号：US10941139B2

  公开（公告）日：2021-03-09

  The present invention relates to cryptophycin compounds of formula (I). The invention also relates to cryptophycin payloads, to cryptophycin conjugates, to compositions containing them and to their therapeutic use, especially as anticancer agents. The invention also relates to the process for preparing these conjugates.

  本发明涉及式（I）的隐球霉素化合物。本发明还涉及隐球菌苷有效载荷、隐球菌苷共轭物、含有它们的组合物及其治疗用途，特别是作为抗癌剂。本发明还涉及制备这些共轭物的工艺。
• Cryptophycin antibody conjugates for the treatment of cancer
  申请人：SANOFI

  公开号：US11007275B2

  公开（公告）日：2021-05-18

  The present disclosure relates to compounds of formula (V): wherein Ab represents an antibody. The disclosure also relates to cryptophycin payloads, as well as to cryptophycin conjugates, to compositions containing them and to their therapeutic use, especially as anticancer agents. The disclosure also relates to the process for preparing these conjugates.

  本公开涉及式（V）化合物： 其中 Ab 代表抗体。本公开还涉及隐球菌苷有效载荷、隐球菌苷共轭物、含有它们的组合物及其治疗用途，特别是作为抗癌剂。本公开还涉及制备这些共轭物的工艺。
• NOVEL CRYPTOPHYCIN COMPOUNDS AND CONJUGATES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
  申请人：SANOFI

  公开号：EP3371179A1

  公开（公告）日：2018-09-12