trans-4-[([(S)-1-(4-chloro-phenyl)-ethyl]-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethylsulfanyl]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid | 1443020-63-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: trans-4-[([(S)-1-(4-chloro-phenyl)-ethyl]-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethylsulfanyl]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid
• CAS: 1443020-63-0
• 化学式: C₃₀H₃₇ClN₂O₅S
• 分子量: 573.153
• InChiKey: NLALTEYXBFBQLC-HFMPRLQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.04
• 重原子数：
  39.0
• 可旋转键数：
  12.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  87.15
• 氢给体数：
  1.0
• 氢受体数：
  6.0

文献信息

• Cycloalkane carboxylic acid derivatives as CXCR3 receptor antagonists
  申请人：SANOFI

  公开号：EP2601950A1

  公开（公告）日：2013-06-12

  The present invention relates to compounds of formula 1 that are useful as an active ingredient of a medicament for preventive and/or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention relates furthermore to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds and to the novel intermediates used in the preparation of said compounds.

  本发明涉及公式1的化合物 它们可用作预防性和/或治疗由CXCR3趋化因子异常激活引起的疾病的药物的活性成分。本发明还涉及制备所述化合物的方法、包含所述化合物的药物组合物以及用于制备所述化合物的新中间体。
• [EN] CYCLOALKANE CARBOXYLIC ACID DERIVATIVES AS CXCR3 RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS D'ACIDES CYCLOALCANE CARBOXYLIQUES COMME ANTAGONISTES DU RÉCEPTEUR CXCR3
  申请人：SANOFI SA

  公开号：WO2013084013A1

  公开（公告）日：2013-06-13

  The present invention relates to compounds of formula 1 that are useful as an active ingredient of a medicament for preventive and/or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention relates furthermore to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds and to the novel intermediates used in the preparation of said compounds.

  本发明涉及式1化合物，该化合物作为预防性和/或治疗由CXCR3趋化因子异常激活引起的疾病的药物活性成分是有用的。本发明还进一步涉及制备所述化合物的方法、包含所述化合物的药物组合物以及用于制备所述化合物的新的中间体。
• CYCLOALKANE CARBOXYLIC ACID DERIVATIVES AS CXCR3 RECEPTOR ANTAGONISTS
  申请人：Sanofi

  公开号：US20140288106A1

  公开（公告）日：2014-09-25

  The present invention relates to compounds of formula 1 that are useful for the preventive or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention relates furthermore to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds and to novel intermediates used in the preparation of said compounds.

  本发明涉及一种化合物（公式1），其对由CXCR3趋化因子异常激活引起的疾病的预防或治疗具有用处。本发明还涉及制备所述化合物的方法，含有所述化合物的制药组合物以及用于制备所述化合物的新型中间体。
• US9073853B2
  申请人：——

  公开号：US9073853B2

  公开（公告）日：2015-07-07