3.4-Dihydroxy-5-methylbenzoesaeuremethylester | 32263-15-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3.4-Dihydroxy-5-methylbenzoesaeuremethylester
• 英文别名: methyl 3,4-dihydroxy-5-methyl-benzoate；3,4-dihydroxy-5-methyl-benzoic acid methyl ester；Methyl 3,4-dihydroxy-5-methylbenzoate
• CAS: 32263-15-3
• 化学式: C₉H₁₀O₄
• 分子量: 182.176
• InChiKey: CKXDIEXWUOCEOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3.4-Dihydroxy-5-methylbenzoesaeuremethylester 、 1,2-二溴乙烷 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以84%的产率得到甲基8-甲基-2,3-二氢-1,4-苯并二氧杂环己烷-6-羧酸酯
  参考文献：
  名称：

  Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions

  摘要：

  本发明涉及一般式的CGRP拮抗剂 其中A、X、Q和R 1 至R 3 如权利要求书中所定义， 其互变异构体、异构体、二对映异构体、对映异构体、水合物、混合物及其盐和盐的水合物，特别是其与无机或有机酸形成的生理上可接受的盐，含有这些化合物的药物组合物，它们的用途和制备它们的方法。

  公开号：

  US20050256099A1
• 作为产物：
  描述：

  甲醇 、 2-methyl-3,4-dihydroxybenzoic acid 在 盐酸 作用下， 以80%的产率得到3.4-Dihydroxy-5-methylbenzoesaeuremethylester
  参考文献：
  名称：

  Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions

  摘要：

  本发明涉及一般式的CGRP拮抗剂 其中A、X、Q和R 1 至R 3 如权利要求书中所定义， 其互变异构体、异构体、二对映异构体、对映异构体、水合物、混合物及其盐和盐的水合物，特别是其与无机或有机酸形成的生理上可接受的盐，含有这些化合物的药物组合物，它们的用途和制备它们的方法。

  公开号：

  US20050256099A1

文献信息

• Fluorous Dendrimers and Methods for Production Thereof
  申请人：Percec Virgil

  公开号：US20120277460A1

  公开（公告）日：2012-11-01

  The present invention concerns the design of an environmentally friendly and efficient fluorous phase based on dendritic architectures containing short semifluorinated groups on their periphery.

  本发明涉及基于树状结构的含有短半氟化基团的环境友好高效的氟相设计。
• [DE] AUSGEWÄHLTE CGRP-ANTAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL<br/>[EN] SELECTED CGRP ANTAGONISTS, METHODS FOR THE PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS<br/>[FR] ANTAGONISTES DU CGRP SELECTIONNES, PROCEDES DE PRODUCTION DE CES ANTAGONISTES ET LEUR UTILISATION COMME MEDICAMENTS
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2005103037A3

  公开（公告）日：2006-01-12
• COMPLEX LIQUID CRYSTAL DROPLETS
  申请人：Massachusets Institute of Technology

  公开号：US20210041425A1

  公开（公告）日：2021-02-11

  Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of DNA, among other applications. For example, the systems and methods described herein may be used for determining the presence of a contaminant such as bacteria (e.g., detecting pathogenic bacteria in food and water samples which helps to prevent widespread infection, illness, and even death). Advantageously, the systems and methods described herein may not have the drawbacks in current detection technologies including, for example, relatively high costs, long enrichment steps and analysis times, and/or the need for extensive user training. Another advantageous feature provided by the systems and methods described herein includes fabrication in a relatively large scale. In some embodiments, the systems and methods may be used in conjunction with a detector including handheld detectors incorporated with, for example, smartphones (e.g., for the on-site detection of analytes such as pathogenic bacteria).
• US7696195B2
  申请人：——

  公开号：US7696195B2

  公开（公告）日：2010-04-13