N,N-dipropargyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine | 1357114-99-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dipropargyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine
• 英文别名: 12-methyl-N,N-bis(prop-2-ynyl)tetracyclo[8.3.1.18,12.02,7]pentadeca-2,4,6-trien-10-amine
• CAS: 1357114-99-8
• 化学式: C₂₂H₂₅N
• 分子量: 303.447
• InChiKey: UKRIRFLGZJIJGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-dipropargyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine 在 hydrochloric acid diethyl ether 作用下， 以 乙酸乙酯 为溶剂， 生成 N,N-dipropargyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride
  参考文献：
  名称：

  Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities

  摘要：

  The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.11.050
• 作为产物：
  描述：

  7,11-dimethylene-6,7,8,9-tetrahydro-5,9-propano-5H-benzocycloheptene 在 硫酸 、 potassium carbonate 、 溶剂黄146 、 硫脲 、 sodium iodide 作用下， 以 乙醇 、 甲苯 、 乙腈 为溶剂， 反应 36.0h， 生成 N,N-dipropargyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine
  参考文献：
  名称：

  Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities

  摘要：

  The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.11.050

文献信息

• Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities
  作者：Eva Torres、María D. Duque、Marta López-Querol、Martin C. Taylor、Lieve Naesens、Chunlong Ma、Lawrence H. Pinto、Francesc X. Sureda、John M. Kelly、Santiago Vázquez

  DOI：10.1016/j.bmc.2011.11.050

  日期：2012.1

  The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein. (C) 2011 Elsevier Ltd. All rights reserved.