3-(4-Aminobenzyl)-1-methyl-2,4-imidazolidinedione | 258856-22-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-(4-Aminobenzyl)-1-methyl-2,4-imidazolidinedione
• 英文别名: 3-(4-aminobenzyl)-1-methylhydantoin；3-[(4-Aminophenyl)methyl]-1-methyl-2,4-imidazolidinedione；3-[(4-aminophenyl)methyl]-1-methylimidazolidine-2,4-dione
• CAS: 258856-22-3
• 化学式: C₁₁H₁₃N₃O₂
• mdl: MFCD11173675
• 分子量: 219.243
• InChiKey: ILMYXUIPXPUOLI-UHFFFAOYSA-N

物化性质

• 沸点：
  385.4±44.0 °C(Predicted)
• 密度：
  1.333±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-methyl-3-(4-nitrobenzyl)-2,4-imidazolidinedione 在 盐酸 、 tin(ll) chloride 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以98%的产率得到3-(4-Aminobenzyl)-1-methyl-2,4-imidazolidinedione
  参考文献：
  名称：

  THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY

  摘要：

  公开号：

  EP1775298B1

文献信息

• Thienopyrazole Derivative Having PDE7 Inhibitory Activity
  申请人：Inoue Hidekazu

  公开号：US20090131413A1

  公开（公告）日：2009-05-21

  To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R 1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R 2 is methyl; R 3 is a hydrogen atom; and R 4 is a group: —CONR 5 R 6 (in which any one of R 5 and R 6 is a hydrogen atom)].

  为了提供选择性抑制PDE 7的噻唑吡啶衍生物，从而增强细胞cAMP水平。因此，该化合物可用于治疗各种疾病，如过敏性疾病、炎症性疾病或免疫性疾病。该化合物是由以下式子(I)表示的噻唑吡啶化合物：[其中，特别地，R1是环己基、环庚基或四氢吡喃基；R2是甲基；R3是氢原子；R4是一个基团：—CONR5R6（其中R5和R6中的任何一个是氢原子）]。
• BENZOTHIEPIN DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1103552A1

  公开（公告）日：2001-05-30

  The invention provides compounds of the formula: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen atom or an optionally substituted hydrocarbon group; n is an integer of 0 - 3; or salts thereof, which are useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. The present invention relates to an amine compound having an excellent effect of inhibiting production and/or secretion of amyloid-b protein, a production and use thereof. Especially, it is effective for preventing and/or treating, for example, neurodegenerative diseases, amyloid angiopathy, neurological disorders caused by cerebrovascular disorders, and so forth.

  本发明提供了如下式的化合物： 其中，环 A 是任选取代的苯环；R1 是任选取代的非芳香杂环基团；R2 和 R3 独立地是氢原子或任选取代的烃基；n 是 0 - 3 的整数；或其盐，可用作具有促进成骨作用和促进软骨作用的药物。 本发明涉及一种在抑制淀粉样蛋白-b 的产生和/或分泌方面具有卓越效果的胺类化合物及其生产和使用方法。特别是，它对预防和/或治疗神经退行性疾病、淀粉样血管病、脑血管疾病引起的神经系统疾病等有效。
• CHROMONE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1211251A1

  公开（公告）日：2002-06-05

  The invention provides chromone derivatives of the following general formula, a process for preparing such chromone derivatives and a prophylactic and therapeutic agent comprising such chromone derivatives for bone diseases and chondropathy: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 is a hydrogen atom or hydrocarbon group; R3 is a hydrogen atom, hydrocarbon group or halogen; n is an integer of 0-3; or a salt thereof.

  本发明提供了通式如下的铬酮衍生物、制备此类铬酮衍生物的工艺以及包含此类铬酮衍生物的用于骨病和软骨病的预防和治疗剂： 其中，环 A 是任选取代的苯环；R1 是任选取代的非芳香杂环基团；R2 是氢原子或烃基团；R3 是氢原子、烃基团或卤素；n 是 0-3 的整数；或其盐。
• Thienopyrazole derivatives having PDE7 inhibitory activity
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2433943A1

  公开（公告）日：2012-03-28

  To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: -CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].

  提供选择性抑制 PDE 7 并因此提高细胞 cAMP 水平的噻吩并吡唑衍生物。因此，该化合物可用于治疗各种疾病，如过敏性疾病、炎症性疾病或免疫性疾病。该化合物是由下式（I）代表的噻吩并唑化合物： [其中，R1 特别是环己基、环庚基或四氢吡喃基；R2 是甲基；R3 是氢原子；R4 是基团：-CONR5R6（其中 R5 和 R6 中的任一个是氢原子）]。
• Benzothiepine derivatives, their production and use
  申请人：——

  公开号：US20020128308A1

  公开（公告）日：2002-09-12

  The invention provides compounds of the formula: 1 wherein the ring A is an optionally substituted benzene ring; R 1 is an optionally substituted non-aromatic heterocyclic group; R 2 and R 3 are independently hydrogen atom or an optionally substituted hydrocarbon group; n is an integer of 0-3; or salts thereof, which are useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. The present invention relates to an amine compound having an excellent effect of inhibiting production and/or secretion of amyloid-b protein, a production and use thereof. Especially, it is effective for preventing and/or treating, for example, neurodegenerative diseases, amyloid angiopathy, neurological disorders caused by cerebrovascular disorders, and so forth.

  本发明提供了以下式子的化合物： 1 其中环 A 是任选取代的苯环； R 1 是任选取代的非芳香杂环基团； R 2 和 R 3 独立地为氢原子或任选取代的烃基；n 为 0-3 的整数；或其盐，可用作具有促进成骨作用和促进软骨作用的药物。 本发明涉及一种具有良好抑制淀粉样蛋白-b 生成和/或分泌效果的胺类化合物及其生产和使用方法。特别是，它对预防和/或治疗神经退行性疾病、淀粉样血管病、脑血管疾病引起的神经紊乱等有效。