11-hydroxy-2,3-dimethoxy-6-methyl-11H-indeno[1,2-c]isoquinolin-5-one | 1285527-82-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 11-hydroxy-2,3-dimethoxy-6-methyl-11H-indeno[1,2-c]isoquinolin-5-one
• CAS: 1285527-82-3
• 化学式: C₁₉H₁₇NO₄
• 分子量: 323.348
• InChiKey: BUKFZQYHUXULBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  11-hydroxy-2,3-dimethoxy-6-methyl-11H-indeno[1,2-c]isoquinolin-5-one 在 重铬酸吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 2,3-dimethoxy-6-methyl-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
  参考文献：
  名称：

  Suzuki–Miyaura cross-coupling and ring-closing metathesis: a strategic combination to the synthesis of indeno[1,2-c]isoquinolin-5,11-diones

  摘要：

  A variety of diversely substituted isoindeno[1,2-c]isoquinolin-5,11-diones has been readily assembled through a sequence involving a Suzuki-Miyaura cross-coupling reaction with enol phosphates combined with a ring-closing metathesis (RCM) reaction. Intramolecular carbocationic annulation reaction and ultimate oxidation of a latent hydroxyl functionality completed the synthesis of the target titled compounds. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.113
• 作为产物：
  描述：

  2-(6,7-dimethoxy-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)benzaldehyde 在 盐酸 作用下， 以 丙酮 为溶剂， 反应 24.0h， 生成 11-hydroxy-2,3-dimethoxy-6-methyl-11H-indeno[1,2-c]isoquinolin-5-one
  参考文献：
  名称：

  Suzuki–Miyaura cross-coupling and ring-closing metathesis: a strategic combination to the synthesis of indeno[1,2-c]isoquinolin-5,11-diones

  摘要：

  A variety of diversely substituted isoindeno[1,2-c]isoquinolin-5,11-diones has been readily assembled through a sequence involving a Suzuki-Miyaura cross-coupling reaction with enol phosphates combined with a ring-closing metathesis (RCM) reaction. Intramolecular carbocationic annulation reaction and ultimate oxidation of a latent hydroxyl functionality completed the synthesis of the target titled compounds. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.113

文献信息

• METHOD FOR PREPARING INDENOISOQUINOLINE DERIVATIVES
  申请人：National Taiwan Normal University

  公开号：EP3480187A1

  公开（公告）日：2019-05-08

  A method for preparing indenoisoquinoline derivatives represented by the following formula (I) is disclosed, which comprises the following steps: (A) providing a first reactant represented by the following formula (II) and a second reactant represented by the following formula (III): and (B) reacting the first reactant represented by the formula (II) and the second reactant represented by the formula (III) in a solvent and selectively adding R2NH2 therein, to obtain the indenoisoquinoline derivatives represented by the formula (I), wherein, R1, R2, R3, A, X, Y, Z, m and n are defined in the specification.

  本发明公开了一种制备下式（I）所代表的茚并异喹啉衍生物的方法，该方法包括以下步骤： (A) 提供下式（II）代表的第一反应物和下式（III）代表的第二反应物： 和 (B) 将式（II）代表的第一反应物和式（III）代表的第二反应物在溶剂中反应并选择性地加入 R2NH2，得到式（I）代表的茚并异喹啉衍生物，其中 R1、R2、R3、A、X、Y、Z、m 和 n 在说明书中定义。