| 1304495-34-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1304495-34-8
• 化学式: C₂₄H₂₉NO₃Si
• 分子量: 407.585
• InChiKey: MMMDCCBYMCGOTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.17
• 重原子数：
  29.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.4
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  在 μ-oxo-[bis(trifluoroacetoxy)iodo]benzene 作用下， 以 2,2,2-三氟乙醇 为溶剂， 反应 0.5h， 以95%的产率得到spiro[2,3-dihydro-1H-benzo[g]quinoline-4,4'-cyclohexa-2,5-diene]-1',5,10-trione
  参考文献：
  名称：

  Efficient phenolic oxidations using μ-oxo-bridged phenyliodine trifluoroacetate

  摘要：

  The excellent oxidizing behavior of the mu-oxo-bridged phenyliodine trifluoroacetate 1 is revealed during the phenolic oxidations mediated by hypervalent iodine(III) reagents. The use of the mu-oxo-bridged compound 1 instead of PhI(OAc)(2) (PIDA) and PhI(OCOCF3)(2) (PIFA) during the oxidative cyclization of phenols involving carbon-oxygen, carbon-nitrogen, and carbon-carbon bond formations could produce spirocyclized cyclohexadienones in comparable or somewhat better yields. Thus, we have concluded that the unique reagent 1 is a promising alternative to PIDA and PIFA, and the use of reagent 1 as a reasonable choice is recommended for the hypervalent iodine(III)-mediated phenolic oxidations as well as other transformations. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.12.037