2,5-Dichloro-3,4-dimethylthiophen | 57308-91-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 2,5-Dichloro-3,4-dimethylthiophen
• 英文别名: 2,5-dichloro-3,4-dimethyl-thiophene；2,5-Dichloro-3,4-dimethylthiophene
• CAS: 57308-91-5
• 化学式: C₆H₆Cl₂S
• 分子量: 181.086
• InChiKey: HTWIYWBFVTZADL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,5-dichloro-3,4-diiodothiophene 以45%的产率得到
  参考文献：
  名称：

  AYRES B. E.; LONGWORTH S. W.; MCOMIE J. F. W., TETRAHEDRON , 1975, 31, NO 15, 1755-1760

  摘要：

  DOI：

文献信息

• HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME
  申请人：Jachmann Markus

  公开号：US20100137362A1

  公开（公告）日：2010-06-03

  A hydrazide compound represented by the formula (I), an N-oxide thereof or suitable salt thereof: has excellent pesticidal activity.

  一种由式(I)表示的腙酰肼类化合物，其N-氧化物或适当的盐：具有优异的杀虫活性。
• Aldose reductase inhibitors and methods of use thereof
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US10870658B2

  公开（公告）日：2020-12-22

  The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, asthma, and the like.

  本公开涉及新型化合物及其药物组合物，以及促进皮肤健康老化、治疗皮肤疾病、治疗心血管疾病、治疗肾脏疾病、治疗血管生成疾病（如癌症）、治疗组织损伤（如非心脏组织损伤）、治疗演变性心肌梗塞、治疗缺血性损伤，以及用本发明化合物和组合物治疗各种其他疾病（如糖尿病引起的并发症）的方法。其他疾病包括但不限于动脉粥样硬化、冠状动脉疾病、糖尿病肾病、糖尿病神经病变、糖尿病视网膜病变、糖尿病心肌病、皮肤感染、外周血管疾病、中风、哮喘等。
• ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US20200283451A1

  公开（公告）日：2020-09-10

  The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, asthma, and the like.
• US8247431B2
  申请人：——

  公开号：US8247431B2

  公开（公告）日：2012-08-21