N-Benzyl-N'-(3-dimethylamino-propyl)-carbodiimid | 7521-85-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Benzyl-N'-(3-dimethylamino-propyl)-carbodiimid
• 英文别名: 1-Benzyl-3-dimethylaminopropylcarbodiimide
• CAS: 7521-85-9
• 化学式: C₁₃H₁₉N₃
• 分子量: 217.314
• InChiKey: ZHVUOIWXIOKFTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  28
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Water soluble multi-biotin-containing compounds
  申请人：Wilbur Scott D.

  公开号：US20060228325A1

  公开（公告）日：2006-10-12

  Water-soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water-soluble biotin-containing compounds may additionally comprise one or more moieties that confer resistance to cleavage by biotinidase or that is cleavable in vitro or in vivo. The discrete multi-biotin-containing compounds may include a reactive moiety that provides a site for reaction with yet another moiety, such as a targeting, diagnostic or therapeutic functional moiety. Biotinylation reagents comprising water-soluble linker moieties are also disclosed and may additionally comprise a biotinidase protective group. Methods for amplifying the number of sites for binding biotin-binding proteins at a selected target using multi-biotin compounds also are disclosed.

  可溶于水的离散多生物素含有化合物，至少含有三个（3）生物素基团。这些可溶于水的生物素含有化合物可能还包括一个或多个使其对生物素酶的裂解具有抗性的基团，或者在体外或体内可被裂解的基团。这些离散的多生物素含有化合物可能包括一个反应性基团，提供与另一个基团（如靶向、诊断或治疗功能基团）反应的位点。还公开了包含可溶于水的连接基团的生物素化试剂，可能还包括生物素酶保护基团。还公开了使用多生物素化合物扩增在选定靶点上结合生物素结合蛋白的位点数量的方法。
• NEW METHOD FOR PREPARING 3-(4-METHYL-1H-IMIDAZOL-1-YL)-5-(TRIFLUOROMETHYL)BENZENAMINE
  申请人：Esteve Química, S.A.

  公开号：EP3095782A1

  公开（公告）日：2016-11-23

  The present invention relates to a new method for preparing 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-benzenamine. The invention also relates to a new intermediate of formula (XI) used in this method and to a method for preparing nilotinib comprising the step of preparing 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-benzenamine by the method of the invention.

  本发明涉及一种制备3-(4-甲基-1H-咪唑-1-基)-5-(三氟甲基)-苯胺的新方法。本发明还涉及一种在该方法中使用的新的中间体式（XI），以及一种制备尼洛替尼的方法，其中包括通过本发明的方法制备3-(4-甲基-1H-咪唑-1-基)-5-(三氟甲基)-苯胺的步骤。
• Hybrid antibody and process for the production thereof
  申请人：SNOW BRAND MILK PRODUCTS CO., LTD.

  公开号：EP0346087A2

  公开（公告）日：1989-12-13

  A polymer-type hybrid antibody molecule having the capability to recognize two different antigens and a process for the production thereof are disclosed, wherein two kinds of antibody molecules, each having different antigen specificity, are polymerized by cross-linkage of carboxyl groups of carboxyl ends thereof via amino groups. The resultant hybrid antibody can be used, for example, in microdetermination or as a therapeutic agent.

  本发明公开了一种具有识别两种不同抗原能力的聚合物型杂交抗体分子及其生产工艺，其中两种各自具有不同抗原特异性的抗体分子通过氨基交联其羧基末端的羧基而聚合。由此产生的混合抗体可用于微量测定或用作治疗剂等。
• Colony stimulating factor-gelatin conjugate
  申请人：DENKI KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0364980A2

  公开（公告）日：1990-04-25

  Disclosed are a crosslinked gelatin microspheres containing CSF and a water soluble CSF-gelatin conjugate. Both the microspheres and the water soluble conjugate provide an improved CSF stability. They have a high potentiation on the antitumor activity of macrophages in respect of the CSF amount and the time required for macrophage activation and are effective in maintaining their activated state for a long period, compared with the native CSF. The mechanism of macrophage activation by the microspheres containing CSF is mediated via phagocytosis and different from that by native CSF, which is believed to activate macrophages via cell surface receptor. The species specificity of CSF may be absrogated when the CSF is internalized into macrophages through hagocytosis.

  本发明公开了一种含有 CSF 的交联明胶微球和一种水溶性 CSF-明胶共轭物。微球和水溶性共轭物都能提高 CSF 的稳定性。与原生 CSF 相比，它们对巨噬细胞的抗肿瘤活性具有很高的增效作用，与巨噬细胞活化所需的 CSF 量和时间相比，它们能长期有效地维持巨噬细胞的活化状态。含有 CSF 的微球激活巨噬细胞的机制是通过吞噬作用介导的，与原生 CSF 不同，原生 CSF 被认为是通过细胞表面受体激活巨噬细胞的。当 CSF 通过吞噬作用内化到巨噬细胞中时，CSF 的物种特异性可能会消失。
• Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
  申请人：Rutgers, The State University of New Jersey

  公开号：US20020035217A1

  公开（公告）日：2002-03-21

  Polymeric micelles for encapsulation of hydrophobic molecules are provided. Methods and formulations for delivering hydrophobic molecules to a host via these micelles are also provided. Methods of stabilizing liposomes or lipid based formulations by addition of polymeric micelles are also provided.

  提供了用于封装疏水分子的聚合物胶束。还提供了通过这些胶束向宿主输送疏水分子的方法和制剂。还提供了通过添加聚合物胶束稳定脂质体或脂基制剂的方法。