(E)-(4-chlorophenyl)(phenyl)methanone oxime | 2998-99-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-(4-chlorophenyl)(phenyl)methanone oxime
• 英文别名: 4-chloro-benzophenone-seqtrans-oxime；4-Chlor-benzophenon-seqtrans-oxim；syn-Phenyl-(4-chlor-phenyl)-ketoxim；4-Chlor-benzophenon-α(syn-phenyl)-oxim；trans-p-Chlorbenzophenon oxim；anti-4-Chlorbenzophenon-oxim；(NE)-N-[(4-chlorophenyl)-phenylmethylidene]hydroxylamine
• CAS: 2998-99-4
• 化学式: C₁₃H₁₀ClNO
• 分子量: 231.681
• InChiKey: NIMKUYDSEKAHMG-FYWRMAATSA-N

物化性质

• 沸点：
  364.4±34.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-(4-chlorophenyl)(phenyl)methanone oxime 在 cerium(III) chloride 、 silica gel 、 sodium iodide 作用下， 反应 0.13h， 以75%的产率得到N-(4-氯-苯基)-苯酰胺
  参考文献：
  名称：

  Li, Zheng; Lu, Zhong; Ding, Runbo, Journal of Chemical Research, 2006, # 10, p. 668 - 670

  摘要：

  DOI：
• 作为产物：
  描述：

  苯 在 氢氧化钾 、 乙醇 、 盐酸羟胺 作用下， 生成 (E)-(4-chlorophenyl)(phenyl)methanone oxime
  参考文献：
  名称：

  Demuth; Dittrich, Chemische Berichte, 1890, vol. 23, p. 3609

  摘要：

  DOI：

文献信息

• Pt-catalyzed O-silylation of oximes by tri-substituted organosilanes
  作者：Shreeja V. Bhatt、Shreya V. Bhatt、Jean Fotie

  DOI：10.1016/j.tetlet.2019.05.033

  日期：2019.6

  Silylated derivatives of oximes are important intermediates in organic synthesis, and have found application in the preparation of various nitrogen containing compounds including nitriles, amines, nitrones, and hydroxylamines. An efficient method for the O-silylation of aldoximes and ketoximes through a platinum-catalyzed reaction using trisubstituted-hydrosilanes is described. The reaction works well

  肟的甲硅烷基化衍生物是有机合成中的重要中间体，并已发现可用于制备各种含氮化合物，包括腈，胺，硝酮和羟胺。描述了通过使用三取代的氢硅烷的铂催化的反应使醛肟和酮肟的O-甲硅烷基化的有效方法。当使用三乙基硅烷作为甲硅烷基化剂时，该反应对一系列脂族和芳族肟反应良好。此外，还研究了许多三取代的有机硅烷，包括三异丙基硅烷，二乙氧基甲基硅烷，三苯基硅烷和三乙氧基硅烷。
• STITCHED POLYPEPTIDES
  申请人：Verdine Gregory L.

  公开号：US20100184645A1

  公开（公告）日：2010-07-22

  The present invention provides inventive stitched polypeptides, pharmaceutical compositions thereof, and methods of making and using inventive stitched polypeptides.

  本发明提供了创新的缝合多肽，其制药组合物以及制备和使用创新的缝合多肽的方法。
• Regioselective Synthesis of Phenanthridines via Pd(II)-Catalyzed Annulative C(<i>sp</i>²)–H Activation
  作者：Anamika Yadav、Surabhi Upadhyay、Ruchir Kant、Ajay Kumar Srivastava

  DOI：10.1021/acs.joc.3c01234

  日期：2023.10.6

  A robust synthesis of phenanthridines has been described via Pd(II)-catalyzed domino C(sp2)–H activation/N-arylation using oxime esters with aryl acyl peroxides in a highly regioselective manner. This protocol is compatible with acetophenone as well as benzophenone-derived oxime esters and allows modular construction of functionalized phenanthridines with wide tolerance of electronic functionality

  通过 Pd(II) 催化的多米诺骨牌 C(sp 2 )–H 活化/ N-芳基化，使用肟酯与芳基酰基过氧化物以高度区域选择性的方式实现了菲啶的稳健合成。该协议与苯乙酮以及二苯甲酮衍生的肟酯兼容，并允许对电子功能具有广泛耐受性的功能化菲啶进行模块化构建。进行了进一步的转化以合成关键构件，并进行了控制实验以了解合理的反应机制。
• Method of making patterns
  申请人：CIBA-GEIGY AG

  公开号：EP0326516A2

  公开（公告）日：1989-08-02

  A method of making a metallic pattern on a substrate having a surface comprising bare metal in predetermined areas and metal coated by a resist in remaining areas comprises (i) protecting the bare metal by electrodepositing thereon a heat-curable polymeric film having (a) a group which is reactive with an isocyanate group and (b) a blocked isocyanate group, (ii) heating the electrodeposited polymeric film to render it resistant to a solvent with which the resist is removable, (iii) removing the resist from said remaining areas using a solvent which does not remove the electrodeposited polymeric film, thereby exposing metal in said remaining areas, and (iv) etching the metal exposed in step (iii) using an etchant which does not remove the electrodeposited polymeric film, thereby leaving a metallic pattern protected by the electrodeposited polymeric film, which can be removed subsequently using a solvent therefor. The method is useful in the production of printed circuits.

  一种在基底上制作金属图案的方法，该基底的表面包括预定区域的裸金属和剩余区域的抗蚀剂涂层金属，该方法包括 (i) 在裸金属上电沉积一层热固化聚合膜以保护裸金属，该聚合膜具有 (a) 与异氰酸酯基团反应的基团和 (b) 被阻断的异氰酸酯基团、 (ii) 加热电沉积的聚合物薄膜，使其能够耐受可去除抗蚀剂的溶剂、 (iii) 使用不去除电沉积聚合物薄膜的溶剂去除所述剩余区域的抗蚀剂，从而在所述剩余区域暴露金属，以及 (iv) 使用不去除电沉积聚合物薄膜的蚀刻剂蚀刻步骤(iii)中暴露的金属，从而留下受电沉积聚合物薄膜保护的金属图案，随后可使用溶剂将其去除。 该方法适用于印刷电路的生产。
• VEGF-REGULATING PEPTIDES
  申请人：IDP Discovery Pharma, S.L.

  公开号：EP4023295A1

  公开（公告）日：2022-07-06

  The invention provides a peptide or a pharmaceutical salt thereof having a length from 14 to 50 and comprising a sequence having at least a 85% of sequence identity with respect to SEQ ID NO: 1, wherein "m", "n", "p", and "q" represent integers and are selected from 0 and 1; the C-terminal end corresponds to -C(O)R4; and N-terminal end corresponds to -NHR5; the peptide optionally comprising a linker biradical "L" of formula (I) connecting an alpha carbon atom of an amino acid located at position "i" with an alpha carbon atom of an amino acid located at position "i+4" or "i+7" in the peptide sequence SEQ ID NO: 1. The present invention also provides fusion proteins and pharmaceutical compositions comprising the peptides of the invention as well as their use in therapy and, particularly, in the treatment of a disease caused by an increase or reduction in VEGF levels.

  本发明提供了一种多肽或其药用盐，其长度为 14 至 50，包含与 SEQ ID NO：1，其中 "m"、"n"、"p "和 "q "代表整数且选自0和1；C-末端对应于-C(O)R4；N-末端对应于-NHR5；该多肽可选地包括连接位于肽序列SEQ ID NO: 1中 "i "位的氨基酸的α碳原子和位于 "i+4 "或 "i+7 "位的氨基酸的α碳原子的式(I)的连接体双链肽 "L"。 本发明还提供了融合蛋白和包含本发明多肽的药物组合物，以及它们在治疗中的用途，特别是在治疗由血管内皮生长因子水平升高或降低引起的疾病中的用途。