2-acetyl-3-aminopyrido[2,3-b]thiophene | 52505-41-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 2-acetyl-3-aminopyrido[2,3-b]thiophene
• 英文别名: 2-Acetyl-3-aminothieno<2,3-b>pyridin；1-(3-amino-thieno[2,3-b]pyridin-2-yl)-ethanone；1-(3-Aminothieno[2,3-b]pyridin-2-yl)ethanone
• CAS: 52505-41-6
• 化学式: C₉H₈N₂OS
• 分子量: 192.241
• InChiKey: QFDCWBSXZKSRRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  N,N-二甲基甲酰胺二甲基缩醛 、 2-acetyl-3-aminopyrido[2,3-b]thiophene 以 甲醇 为溶剂， 反应 72.0h， 以72%的产率得到3-dimethylamino-1-(3-dimethylaminomethyleneamino-thieno<2,3-b>pyridin-2-yl)-propen-1-one
  参考文献：
  名称：

  Novel Thienopyridines

  摘要：

  A number of novel thieno[2,3-b]pyridines were prepared from the reaction of 1 with unsaturated haloalkanes, and by the reaction of the amino ketones 9 and 10 with DMF dimethylacetal or triethyl orthoformate. The synthesis of novel thieno[2,3-c] and [3,2-c] pyridines, and a thieno[2,3-b;4,5-b']dipyridine are also reported.

  DOI：

  10.1002/prac.19923340606
• 作为产物：
  描述：

  2-磺酰基烟腈 、 一氯丙酮 在 氢氧化钾 作用下， 生成 2-acetyl-3-aminopyrido[2,3-b]thiophene
  参考文献：
  名称：

  Guerrera; Siracusa; Tornetta, Farmaco, Edizione Scientifica, 1976, vol. 31, # 1, p. 21 - 30

  摘要：

  DOI：

文献信息

• Straightforward Synthesis of 2-Acetyl-Substituted Benzo[b]thiophenes
  作者：Julien Debray、Florence Popowycz、Marc Lemaire

  DOI：10.1055/s-0032-1317674

  日期：——

  Described herein is a green one-step protocol for the preparation of substituted 2-acetylbenzo[b]thiophenes from commercially available aromatic halides. This efficient method has the advantage of using water as the reaction medium, resulting in a high yield of pure cyclized products. Two scaffold types have been prepared using this general procedure: 2-acetylbenzo[b]thiophenes and 2-acetyl-3-aminobenzo[b]thiophenes, both crystallized directly from the reaction mixture, due to their low solubility with water, and without the need for an additional purification step.
• Guerrera; Siracusa; Tornetta, Farmaco, Edizione Scientifica, 1976, vol. 31, # 1, p. 21 - 30
  作者：Guerrera、Siracusa、Tornetta

  DOI：——

  日期：——
• GUERRERA F.; SIRACUSA M. A.; TORNETTA B., FARMACO. ED. SCI. <FSTE-AX>, 1976, 31, NO 1, 21-30
  作者：GUERRERA F.、 SIRACUSA M. A.、 TORNETTA B.

  DOI：——

  日期：——
• Novel Thienopyridines
  作者：A. D. Dunn、R. Norrie

  DOI：10.1002/prac.19923340606

  日期：——

  A number of novel thieno[2,3-b]pyridines were prepared from the reaction of 1 with unsaturated haloalkanes, and by the reaction of the amino ketones 9 and 10 with DMF dimethylacetal or triethyl orthoformate. The synthesis of novel thieno[2,3-c] and [3,2-c] pyridines, and a thieno[2,3-b;4,5-b']dipyridine are also reported.