2-(2-cyclohexylaminobenzylsulfinyl)-1-(2-pyridyl)imidazole | 117323-69-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-cyclohexylaminobenzylsulfinyl)-1-(2-pyridyl)imidazole
• 英文别名: N-cyclohexyl-2-[(1-pyridin-2-ylimidazol-2-yl)sulfinylmethyl]aniline
• CAS: 117323-69-0
• 化学式: C₂₁H₂₄N₄OS
• 分子量: 380.514
• InChiKey: HLYIDMKPDUKRNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  79
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Anti-ulcer composition containing imidazole derivative
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：EP0584588A1

  公开（公告）日：1994-03-02

  Disclosed is an anti-ulcer composition to be dissolved in stomach to become directly into contact with walls of the stomach which comprises 100 weight parts of an imidazole derivative of the formula: wherein each of R¹ and R² is hydrogen, substituted or unsubstituted alkyl, alkoxyalkyl, cycloalkyl, aryl, aralkyl, or R¹ and R² are combined to form hetero ring; each of R³, R⁴, R⁵ and R⁶ is hydrogen, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkyl, aryl, aryloxy, alkoxycarbonyl, nitro, amino, acyl, or R³ is combined with R² to form heteroring; R⁷ is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylcarbonyl, or S-containing heteroring; and each of R⁸ and R⁹ is hydrogen, halogen, substituted or unsubstituted alkoxy, unsubstituted or substituted alkyl, alkoxycarbonyl, aralkyl, nitro, amino, acyl, substituted or unsubstituted aryl, or R⁸ and R⁹ are combined to form alkylene, and 50 - 2,000 weigt parts of a basic material.

  揭示了一种抗溃疡组合物，可在胃中溶解，直接与胃壁接触，包括以下成分：100重量部分的一种咪唑衍生物，其化学式为：其中R¹和R²中的每一个是氢、取代或未取代的烷基、烷氧基烷基、环烷基、芳基、芳基烷基，或R¹和R²组合形成杂环；R³、R⁴、R⁵和R⁶中的每一个是氢、卤素、取代或未取代的烷氧基、取代或未取代的烷基、芳基、芳氧基、烷氧羰基、硝基、氨基、酰基，或R³与R²结合形成杂环；R⁷是氢、取代或未取代的烷基、取代或未取代的芳基、取代或未取代的芳基羰基，或含S的杂环；R⁸和R⁹中的每一个是氢、卤素、取代或未取代的烷氧基、未取代或取代的烷基、烷氧羰基、芳基烷基、硝基、氨基、酰基、取代或未取代的芳基，或R⁸和R⁹组合形成亚烷基，以及50-2,000重量部分的一种碱性物质。
• Imidazole derivatives, processes for the preparation of the same, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments of therapeutic value, and intermediates formed during said processes
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0270091A1

  公开（公告）日：1988-06-08

  Novel imidazole of the formula: wherein Ring A is pyridyl group or a substituted pyridyl group; Ring B is phenyl group or a substituted phenyl group; R1 and R2 are hydrogen atom or are combined together to form a group of the formula: --(CH2 )q-; m is 1 or 2; n is 0, 1 or 2; and q is 3 or 4, or a salt thereof are disclosed. Said derivative (I) and a salt thereof are useful an anti-ulcer agents. Processes for the preparation of such derivatives are also provided, together with chemical intermediates formed during said processes. Pharmaceutical compositions comprising the same are further provided. The use of such compounds is also provided for the manufacture of medicaments of therapeutic value.

  本发明公开了式如下的新型咪唑：其中环 A 是吡啶基或取代的吡啶基；环 B 是苯基或取代的苯基；R1 和 R2 是氢原子或结合在一起形成式如下的基团：--(CH2 )q-；m 是 1 或 2；n 是 0、1 或 2；q 是 3 或 4，或其盐。 上述衍生物 (I) 及其盐可用于抗溃疡剂。 本发明还提供了制备此类衍生物的工艺，以及在上述工艺中形成的化学中间体。 本发明还提供了包含上述衍生物的药物组合物。 本发明还提供了此类化合物在制造具有治疗价值的药物中的用途。
• Use of imidazole derivative for antihypertensive agent
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：EP0633026A1

  公开（公告）日：1995-01-11

  The disclosed antihypertensive agent comprises an imidazole derivative of the formula: wherein each of R¹ and R² is hydrogen, substituted or unsubstituted alkyl, alkoxyalkyl, cycloalkyl, aryl, aralkyl, or R¹ and R² are combined to form hetero ring; each of R3, R4, R⁵ and R⁶ is hydrogen, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkyl, aryl, aryloxy, alkoxycarbonyl, nitro, amino, acyl, or R³ is combined with R² to form heteroring; R⁷ is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylcarbonyl, or S-containing heteroring; each of R⁸and R⁹ is hydrogen, halogen, substituted or unsubstituted alkoxy, unsubstituted or substituted alkyl, alkoxycarbonyl, aralkyl, nitro, amino, acyl, substituted or unsubstituted aryl, or R⁸ and R⁹ are combined to from alkylene; and n is 0 or 1.

  所公开的降压制剂包括式中的咪唑衍生物： 其中R¹和R²各自为氢、取代或未取代的烷基、烷氧基烷基、环烷基、芳基、芳烷基，或R¹和R²结合形成杂环；R3、R4、R⁵和R⁶各自为氢、卤素、取代或未取代的烷氧基、取代或未取代的烷基、芳基、芳氧基、烷氧基羰基、硝基、氨基、酰基，或R³与R²结合形成杂环；R⁷ 是氢、取代或未取代的烷基、取代或未取代的芳基、取代或未取代的芳羰基或含 S 的杂环；R⁸ 和 R⁹ 中的每一个是氢、卤素、取代或未取代的烷氧基、未取代或取代的 烷基、烷氧羰基、芳基、硝基、氨基、酰基、取代或未取代的芳基，或者 R⁸ 和 R⁹ 组合为亚烷基；以及 n 是 0 或 1。
• US4996217A
  申请人：——

  公开号：US4996217A

  公开（公告）日：1991-02-26
• US5002945A
  申请人：——

  公开号：US5002945A

  公开（公告）日：1991-03-26