(-)-((2S,3R)-1-methyl-2-(pyridin-3-yl)pyrrolidin-3-yl)methanamine | 272124-60-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (-)-((2S,3R)-1-methyl-2-(pyridin-3-yl)pyrrolidin-3-yl)methanamine
• 英文别名: (3'R)-aminomethylnicotine；((2S,3R)-1-methyl-2-(pyridine-3-yl)pyrrolidin-3-yl)methanamine；(-)-trans 3'-Aminomethyl Nicotine；[(2S,3R)-1-methyl-2-pyridin-3-ylpyrrolidin-3-yl]methanamine
• CAS: 272124-60-4
• 化学式: C₁₁H₁₇N₃
• 分子量: 191.276
• InChiKey: IUMCSWXAFXSTAI-KOLCDFICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (1-Methyl-2-(pyridin-3-yl)pyrrolidin-3-yl)methanamine 生成 (+)-((2R,3S)-1-methyl-2-(pyridin-3-yl)pyrrolidin-3-yl)methanamine 、 (-)-((2S,3R)-1-methyl-2-(pyridin-3-yl)pyrrolidin-3-yl)methanamine
  参考文献：
  名称：

  [EN] ENANTIOPURE HAPTENS FOR NICOTINE VACCINE DEVELOPMENT
  [FR] HAPTÈNES ÉNANTIOPURS POUR DÉVELOPPER DES VACCINS CONTRE LA NICOTINE

  摘要：

  该发明提供了手性半抗原(-)-3'-AmNic和(-)-N4N，用于在患有尼古丁或烟草成瘾或习惯的患者中产生特异性于(-)-尼古丁的抗体。这些半抗原可以与适当的载体蛋白结合，并作为抗原混合物施用给患者，可选地包括佐剂。

  公开号：

  WO2015179403A1

文献信息

• Method of producing 6-substituted (s)-Nicotine derivatives and intermediate compounds
  申请人：——

  公开号：US20030187270A1

  公开（公告）日：2003-10-02

  A method of producing a 6-substituted (S)-nicotine derivative with the general formula (III), wherein R is an optionally substituted alkyl, alkenyl, alkynyl, amido or amino group, optionally coupled to a carrier protein, is disclosed. An intermediate compound useful in the method is also comprised by the invention. The formula of the compound is (A) in which A represents the cationic radical of an organic nitrogen base, Y represents an anion formed by an electrophilic compound.

  揭示了一种生产具有通式（III）的6-取代（S）-尼古丁衍生物的方法，其中R是一个可选择取代的烷基，烯基，炔基，酰胺或氨基团，可选择地与载体蛋白耦合。该方法中还包括一种在该方法中有用的中间化合物。该化合物的化学式为（A），其中A代表有机氮碱的阳离子基团，Y代表由亲电性化合物形成的阴离子。
• Hapten-carrier conjugates and uses thereof
  申请人：Bachmann F. Martin

  公开号：US20050281845A1

  公开（公告）日：2005-12-22

  The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.

  本发明提供了一种包含半抗原与载体的共轭物的组合物，其具有有序和重复的排列方式，并提供了制备这种组合物的方法。本发明的共轭物和组合物可以包含各种半抗原，包括激素、毒素和药物，特别是成瘾药物如尼古丁。本发明的组合物和共轭物可用于诱导免疫反应，用于各种治疗、预防和诊断方案。在某些实施例中，使用本发明的共轭物、组合物和方法产生的免疫反应可用于预防或治疗药物成瘾及与药物成瘾相关的疾病。
• MULTIVALENT SYNTHETIC NANOCARRIER VACCINES
  申请人：Bratzler Robert L.

  公开号：US20110293701A1

  公开（公告）日：2011-12-01

  The invention relates, at least in part, to compositions comprising populations of synthetic nanocarriers that comprise different sets of antigens as well as related methods.

  该发明涉及至少部分包含不同抗原集合的合成纳米载体群体的组成物，以及相关方法。
• ANTI-DRUG VACCINES
  申请人：Deng Shi-Xian

  公开号：US20120269828A1

  公开（公告）日：2012-10-25

  The present invention relates to anti-drug vaccines based on conjugates between the drug and a non-immunogenic carrier protein. In preferred embodiments, it provides for anti-cocaine vaccines and their use to diminish the effects and/or use of cocaine in a subject.

  本发明涉及基于药物与非免疫原性载体蛋白之间的共轭物的抗药物疫苗。在优选实施例中，本发明提供了抗可卡因疫苗及其在减轻可卡因在受试者中的影响和/或使用方面的用途。
• Hapten-Carrier Conjugates and Uses Thereof
  申请人：BACHMANN Martin F.

  公开号：US20130142821A1

  公开（公告）日：2013-06-06

  The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.

  本发明提供了一种由载体和半抗原共价结合的有序和重复阵列的组合物及其制备方法。该发明的共价结合物和组合物可以包含多种半抗原，包括激素、毒素和药物，特别是成瘾药物如尼古丁。本发明的组合物和共价结合物可用于诱导对半抗原的免疫反应，这对于各种治疗、预防和诊断方案都有用。在某些实施例中，使用本发明的共价结合物、组合物和方法产生的免疫反应可用于预防或治疗药物成瘾及与药物成瘾相关的疾病。