7-chloro-6,6,7,7-tetrafluoro-4-iodo-2-methyl-heptan-1-ol | 1028207-61-5

• 分子结构分类: 有机化合物 - 有机卤素化合物
• 英文名称: 7-chloro-6,6,7,7-tetrafluoro-4-iodo-2-methyl-heptan-1-ol
• CAS: 1028207-61-5
• 化学式: C₈H₁₂ClF₄IO
• 分子量: 362.534
• InChiKey: APVSRKUEEWPLCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.67
• 重原子数：
  15.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  7-chloro-6,6,7,7-tetrafluoro-4-iodo-2-methyl-heptan-1-ol 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 反应 10.0h， 生成 7-chloro-6,6,7,7-tetrafluoro-2-methyl-hept-4-en-1-ol 、 7-chloro-6,6,7,7-tetrafluoro-2-methyl-hept-4-en-1-ol
  参考文献：
  名称：

  Fluoroalkylation of pent-4-en-1-ols initiated by sodium dithionite to synthesize fluorine-containing tetrahydrofuran derivatives

  摘要：

  Fluoroalkylation of pent-4-en-1-ols with RCF2I initiated by Na2S2O4 was carried out at 5-10 degrees C in aqueous acetonitrile affording corresponding adducts, which were converted to fluoroalkyl tetrahydrofurans by heating in DMF or acetonitrile, providing a convenient method for the synthesis of fluorine-containing tetrahydrofuran derivatives. (c) 2007 Published by Elsevier B.V.

  DOI：

  10.1016/j.jfluchem.2007.05.013
• 作为产物：
  描述：

  1-氯-2-碘四氟乙烷, 、 2-methylpent-4-en-1-ol 在 sodium dithionite 、 碳酸氢钠 作用下， 以 水 、 乙腈 为溶剂， 反应 1.0h， 生成 7-chloro-6,6,7,7-tetrafluoro-4-iodo-2-methyl-heptan-1-ol
  参考文献：
  名称：

  Fluoroalkylation of pent-4-en-1-ols initiated by sodium dithionite to synthesize fluorine-containing tetrahydrofuran derivatives

  摘要：

  Fluoroalkylation of pent-4-en-1-ols with RCF2I initiated by Na2S2O4 was carried out at 5-10 degrees C in aqueous acetonitrile affording corresponding adducts, which were converted to fluoroalkyl tetrahydrofurans by heating in DMF or acetonitrile, providing a convenient method for the synthesis of fluorine-containing tetrahydrofuran derivatives. (c) 2007 Published by Elsevier B.V.

  DOI：

  10.1016/j.jfluchem.2007.05.013