3,5-Dinitro-2-tert-butylmercapto-pyridin | 38082-92-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3,5-Dinitro-2-tert-butylmercapto-pyridin
• 英文别名: 2-tert-butylsulfanyl-3,5-dinitro-pyridine；2-Tert-butylsulfanyl-3,5-dinitropyridine
• CAS: 38082-92-7
• 化学式: C₉H₁₁N₃O₄S
• 分子量: 257.27
• InChiKey: NOZQZEHAHNTHMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  130
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• HINDERED DISULFIDE DRUG CONJUGATES
  申请人：Genentech, Inc.

  公开号：US20170112891A1

  公开（公告）日：2017-04-27

  The invention relates generally to disulfide drug conjugates wherein a linker comprising a sulfur-bearing carbon atom substituted with at least one hydrocarbyl or substituted hydrocarbyl is conjugated by a disulfide bond to a cysteine sulfur atom of a targeting carrier, and wherein the linker is further conjugated to a drug moiety. The invention further relates to activated linker-drug conjugates suitable for conjugation to a targeting carrier by a disulfide bond. The invention further relates to methods for preparing hindered disulfide drug conjugates.