1,6-Dichlor-hexen-(3) | 64730-61-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: 1,6-Dichlor-hexen-(3)
• 英文别名: trans-1,6-Dichlorhexen-3；1,6-dichloro-hex-3t-ene；(E)-1,6-dichlorohex-3-ene
• CAS: 64730-61-6
• 化学式: C₆H₁₀Cl₂
• 分子量: 153.051
• InChiKey: JYPUYHQUARVUER-OWOJBTEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  8.0
• 可旋转键数：
  4.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  1,6-Dichlor-hexen-(3) 、 Bis-chlormethyl-zink 生成 trans-1,2-Bis-(β-chlorethyl)-cyclopropan
  参考文献：
  名称：

  Wittig,G.; Wingler,F., Chemische Berichte, 1964, vol. 97, p. 2146 - 2164

  摘要：

  DOI：
• 作为产物：
  描述：

  (3E)-3-己烯-1,6-二醇 在 吡啶 、 氯化亚砜 作用下， 生成 1,6-Dichlor-hexen-(3)
  参考文献：
  名称：

  Wittig,G.; Wingler,F., Chemische Berichte, 1964, vol. 97, p. 2146 - 2164

  摘要：

  DOI：

文献信息

• CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING
  申请人：Reiley Pharmaceuticals, Inc.

  公开号：US20150374858A1

  公开（公告）日：2015-12-31

  Conjugates derived from non-steroidal anti-inflammatory drugs (NSAIDs) and methods of use thereof are disclosed, useful for, inter alia, identifying and localizing the site of pathology and/or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The NSAID-based conjugates contain an imaging moiety. The conjugates concentrate at sites of increased cyclooxygenase expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and/or location. Identifying areas of increased COX expressing can also aid in screening for infections.

  披露了来自非甾体抗炎药（NSAIDs）的衍生物及其使用方法，这对于识别和定位患者疼痛感觉的病理和/或炎症部位；识别原发、继发、良性或恶性肿瘤的部位；以及诊断感染或确认或排除疑似感染非常有用。基于NSAID的偶联物含有成像基团。这些偶联物在环氧化酶表达增加的部位富集，从而揭示了前列腺素产生增加的部位，这与疼痛和炎症有关，并与肿瘤存在和/或位置有关。识别COX表达增加的区域也有助于筛查感染。
• Metathesis syntheses of pheromones or their components
  申请人：——

  公开号：US20020022741A1

  公开（公告）日：2002-02-21

  The present invention relates to metathesis syntheses for insect sex-attractant pheromones or their components, such as E-5-decenyl acetate, the major component of the Peach Twig Borer pheromone; (5R, 6S)-6-acetoxy-5-hexadecanolide, the mosquito oviposition attractant pheromone; E9, Z11-hexadecadienal, the pecan nut casebearer moth pheromone; 9-tetradecenyl formate, an analog of the Diamondback Moth (DBM) pheromone; 11-tetradecenyl acetate, the Omnivorous Leafroller (OLR) pheromone; E-4-tridecenyl acetate, the major component of the Tomato Pinworm (TPW) pheromone; E,E-8,10-dodecadienol, the Codling Moth (CM) pheromone. The syntheses preferably employ a Class I-IV metathesis catalyst, entail few reaction steps, use generally commercially available starting materials, and have relatively short process times. These syntheses produce good yields without the need for expensive or sophisticated equipment. The invention also provides an inexpensive route for producing omega-haloalkenols by cross-metathesizing alpha-omega-diacetoxy alkenes and alpha-omega-dihalides to yield omega-haloalkenols, which are easily converted into omega-haloalkanols under traditional hydrogenation methods.

  本发明涉及对昆虫性诱素或其组分进行交换合成，如E-5-癸烯醇醋酸酯，桃枝蠕蛾性信息素的主要成分；（5R, 6S）-6-乙酰氧基-5-十六醇内酯，蚊子产卵引诱素；E9, Z11-癸二烯醛，山核桃果蛾性信息素；9-十四烯酸甲酯，菜青虫性信息素的类似物；11-十四烯醇醋酸酯，杂食卷叶蛾性信息素；E-4-十三烯醇醋酸酯，番茄针孔螟性信息素的主要成分；E,E-8,10-十二二烯醇，苹果蛾性信息素。这些合成通常采用I-IV类交换催化剂，步骤较少，使用通常易得的起始物质，并具有相对较短的工艺时间。这些合成产量良好，无需昂贵或复杂的设备。该发明还提供了通过交叉交换α-Ω-二乙酰基烯烃和α-Ω-二卤代烃来产生Ω-卤代烯醇的廉价途径，后者可以在传统的氢化方法下轻松转化为Ω-卤代烷醇。
• [EN] PROCESS FOR PREPARING PERFUMING INTERMEDIATE<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN INTERMÉDIAIRE PARFUMANT
  申请人：FIRMENICH & CIE

  公开号：WO2021176009A1

  公开（公告）日：2021-09-10

  The present invention relates to the field of organic synthesis and more specifically it concerns a process for preparing compound of formula (I) by a cross metathesis reaction. Said compound of formula (I) is valuable new chemical intermediate for producing perfuming ingredients and is also part of the present invention.

  本发明涉及有机合成领域，更具体地涉及一种通过交叉醚交换反应制备化合物(I)的方法。所述化合物(I)是用于生产香料成分的有价值的新化学中间体，也是本发明的一部分。
• Latex d'interpolymère et procédé de préparation
  申请人：RHONE-POULENC SPECIALITES CHIMIQUES

  公开号：EP0052561A1

  公开（公告）日：1982-05-26

  Latex d'interpolymère et procédé de préparation. Lesdits latex sont des dispersions aqueuses de particules de diamètre compris essentiellement entre 0,1 et 1 µm d'un interpolymère composé d'un copolymère A de butadiène, de styrène et d'au moins un acide carboxylique insaturé éthylénique et d'un polymère B de bis(2-chloroéthyl)vinylphosphonate au moins en partie greffé sur le copolymère A. Ils sont utilisables notamment comme liants, en particulier dans l'industrie du couchage du papier et dans l'industrie textile.

  互聚物胶乳及其制备方法 上述胶乳是一种互聚物的水性分散体，其颗粒直径基本在 0.1 至 1 微米之间，该互聚物由丁二烯、苯乙烯和至少一种乙烯基不饱和羧酸的共聚物 A 以及至少部分接枝到共聚物 A 上的乙烯基膦酸双（2-氯乙基）聚合物 B 组成。
• METHODS OF MAKING ORGANIC COMPOUNDS BY METATHESIS
  申请人：Elevance Renewable Sciences, Inc.

  公开号：EP3281931A1

  公开（公告）日：2018-02-14

  Described are methods of making organic compounds by metathesis chemistry. The methods of the invention are particularly useful for making industrially-important organic compounds beginning with starting compositions derived from renewable feedstocks, such as natural oils. The methods make use of a cross-metathesis step with an olefin compound to produce functionalized alkene intermediates having a pre-determined double bond position. Once isolated, the functionalized alkene intermediate can be self-metathesized or cross-metathesized (e.g., with a second functionalized alkene) to produce the desired organic compound or a precursor thereto. The method may be used to make bifunctional organic compounds, such as diacids, diesters, dicarboxylate salts, acid/esters, acid/amines, acid/alcohols, acid/aldehydes, acid/ketones, acid/halides, acid/nitriles, ester/amines, ester/alcohols, ester/aldehydes, ester/ketones, ester/halides, ester/nitriles, and the like.

  本发明描述了通过偏合成化学制造有机化合物的方法。本发明的方法特别适用于从可再生原料（如天然油）中提取的起始组合物开始制造工业上重要的有机化合物。这些方法利用与烯烃化合物的交叉甲基化步骤，生成具有预定双键位置的官能化烯中间体。一旦分离出来，官能化烯中间体可进行自甲基化或交叉甲基化（例如与第二种官能化烯），以生产所需的有机化合物或其前体。该方法可用于制造双官能团有机化合物，如二酸、二酯、二羧酸盐、酸/酯、酸/胺、酸/醇、酸/醛、酸/酮、酸/卤化物、酸/腈、酯/胺、酯/醇、酯/醛、酯/酮、酯/卤化物、酯/腈等。