4-{2-[4-(二甲基氨基)苯基]乙烯基}-1-乙基吡啶鎓碘化物 | 101038-58-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-{2-[4-(二甲基氨基)苯基]乙烯基}-1-乙基吡啶鎓碘化物
• 英文名称: 4-[4-(dimethylamino)styryl]-1-ethylpyridinium iodide
• 英文别名: 4-{(E)-2-[4-(dimethylamino)phenyl]-1-ethenyl}-1-ethylpyridinium iodide；(E)-4-(4-(dimethylamino)styryl)-1-ethylpyridinium iodide；1-ethyl-4-(4-dimethylamino-trans-styryl)-pyridinium; iodide；1-Aethyl-4-(4-dimethylamino-trans-styryl)-pyridinium; Jodid；4-[2-(1-ethylpyridin-1-ium-4-yl)ethenyl]-N,N-dimethylaniline;iodide
• CAS: 101038-58-8；29519-52-6
• 化学式: C₁₇H₂₁N₂*I
• 分子量: 380.272
• InChiKey: QALDEYCJTBAWJV-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.23
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  7.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲基吡啶 在 哌啶 作用下， 以 乙醇 为溶剂， 生成 4-{2-[4-(二甲基氨基)苯基]乙烯基}-1-乙基吡啶鎓碘化物
  参考文献：
  名称：

  A side-chain engineering strategy for constructing fluorescent dyes with direct and ultrafast self-delivery to living cells

  摘要：

  通过侧链工程策略，可以通过微调跨膜过程的吸附和脱附能力，显著改善染料的输送，从而实现超低负载生物成像和深层组织穿透。

  DOI：

  10.1039/c9sc05875c

文献信息

• Styryl dyes. Synthesis and study of the solid-state [2+2] autophotocycloaddition by NMR spectroscopy and X-ray diffraction
  作者：A. I. Vedernikov、L. G. Kuz’mina、S. K. Sazonov、N. A. Lobova、P. S. Loginov、A. V. Churakov、Yu. A. Strelenko、J. A. K. Howard、M. V. Alfimov、S. P. Gromov

  DOI：10.1007/s11172-007-0289-4

  日期：2007.9

  benzene fragment of styryl dyes extend the range of the mutual orientations of the molecules in the dimeric pairs, resulting in the formation of two or even four isomeric cyclobutanes in the PCA reactions. The structures of some dyes were established by X-ray diffraction. In the overwhelming majority of the structures, one of two packing modes, either syn-head-to-tail or syn-head-to-head, with extensive

  合成了吡啶和苯并噻唑系列的新型苯乙烯基染料，目的是研究固态 [2+2] 自光环加成 (PCA) 反应。1H NMR 光谱表明，对于大多数研究中的化合物，染料多晶薄膜的可见光照射提供了环丁烷衍生物。光反应速率取决于染料的结构，对于杂环部分含有短 N 取代基并在可见光区具有强吸收的化合物，光反应速率更高。在苯环中带有电子释放取代基的染料在 syn-head-to-tail 二聚体对中经历立体有择的 PCA，得到环丁烷衍生物的唯一 rctt 异构体。苯乙烯基染料苯片段中的吸电子和大取代基扩大了二聚体对中分子的相互取向范围，导致在 PCA 反应中形成两个甚至四个异构环丁烷。一些染料的结构是通过 X 射线衍射确定的。在绝大多数结构中，观察到具有广泛堆叠相互作用的两种包装模式之一，syn-head-to-tail 或 syn-head-to-head。在苯环中含有庞大的 N+(Et)Me2 取代基的双
• Solvent-Free Condensation of Methyl Pyridinium and Quinolinium Salts with Aldehydes Catalyzed by DBU
  作者：Linda Loucif Seiad、Didier Villemin、Nathalie Bar、Messaoud Hachemi

  DOI：10.1080/00397911.2010.528573

  日期：2012.3.1

  Abstract Methylpyridinium and methylquinolinium salts were condensed under solvent-free conditions with aromatic aldehydes in the presence of 1,8-diazabicyclo[5.4.]undec-7-ene (DBU) as catalyst, by grinding at room temperature. The products are dyes or useful intermediates. The DBU can be easily recycled and reused. GRAPHICAL ABSTRACT

  摘要 在1,8-二氮杂双环[5.4.]十一碳-7-烯（DBU）催化剂存在下，在无溶剂条件下，将甲基吡啶鎓和甲基喹啉鎓盐与芳香醛缩合，在室温下研磨。产品为染料或有用的中间体。DBU 可以轻松回收和再利用。图形概要
• Twisted intramolecular charge transfer (TICT) based fluorescent probe for lighting up serum albumin with high sensitivity in physiological conditions
  作者：Peng Zhang、Xinjie Guo、Yuzhe Xiao、Qian Zhang、Caifeng Ding

  DOI：10.1016/j.saa.2019.117318

  日期：2019.12

  Accurate detection of human serum albumin (HSA) in biological samples is quite meaningful for early disease diagnosis and treatment. Herein, a novel fluorescent probe 1-ethyl-4-[2-[4-(diethylamino)-2-hydroxyphenyl]ethenyl]]-pyridinium salt (DEHP) was developed for HSA determination. The inherent fluorescence of DEHP is essentially negligible at physiological conditions assigned to the well-developed

  准确检测生物样品中的人血清白蛋白（HSA）对于早期疾病的诊断和治疗非常有意义。本文中，开发了一种新型的荧光探针1-乙基-4- [2- [4-（二乙基氨基）-2-羟基苯基]乙烯基]]吡啶鎓盐（DEHP）用于HSA测定。在分配给发达的扭曲分子内电荷转移（TICT）方案的生理条件下，DEHP的固有荧光基本上可以忽略不计。当DEHP进入蛋白质HSA的疏水腔时，由于抑制了TICT程序，因此添加了HSA引发了迷人的荧光灯点亮。这种结合导致HSA的荧光反应开启，检测限为4.8 nM。经过全面调查，已证明DEHP和HSA之间的强结合是特定位点相关的。另外，由于在实际血清检测中的使用，该探针暗示了巨大的辅助临床诊断的潜力。细胞成像还显示该探针有望在细胞水平上监测HSA的生产过程。
• TWO -PHOTON UPCONVERTING DYES AND APPLICATIONS
  申请人：——

  公开号：US20030022105A1

  公开（公告）日：2003-01-30

  The present invention is directed to styryl dyes having the formula: 1 wherein D is an electron donating group; Q is an electron acceptor selected from the group consisting of electron acceptors having the formulae: 2 W is an electron accepting group, R 3 is selected from the group consisting of substituted or unsubstituted alkyl or substituted or unsubstituted aryl moieties, n is an integer from 0 to 4, A, B, and C are substituents of their rings and are each independently selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, sulfoalkyl, carboxyalkyl, and hydrogen, and Y is a counterion and compositions thereof. The dyes and compositions exhibit superior two-photon absorption cross-sections and are useful in two-photon pumped cavity lasing, two-photon pumped up-conversion lasing, optical power limiting, optical power stabilization, optical signal reshaping, and infrared beam detection and indication. The present invention is also directed to a multiphasic nanostructured composite including a glass having pores, an optically active coating material on the pore surface, such as a sytryl dye of the present invention, and a polymeric material in the pores. Optionally, the polymeric material can have a second optically active material dispersed therein. These composites are useful in producing multifunctional optical materials, such as broadly tunable lasers. The present invention is also directed to a method for killing cells and viruses. The method includes providing proximate to the cells or viruses a photosensitizer, such as a porphyrin, and a two-photon upconverting dye, such as a styryl dye of the present invention. The dye is then exposed to light in the presence of oxygen under conditions effective to produce a cytotoxic effect on the cells or viruses. These methods are especially useful to kill cells and viruses in biological materials, such as in photodynamic therapy of tumors and cancers or blood purification protocols. In another aspect, the present invention discloses media and methods for recording data. A three-dimensional matrix including a plurality of dye molecules, such a styryl dye molecule of the present invention, is provided. A first volume element in the matrix is exposed to actinic radiation for a duration and at an intensity effective to alter detectably a fraction between 0.3 and 0.7 of the dye molecules contained therein. The detectably altered dye molecules are substantially uniformly dispersed in the first volume element. The data storage methods and media of the present invention have approximately 10 12 volume elements per square centimeter, and each of the volume elements can store a single bit, digital information of approximately 8 bits, or analog information. The data storage methods and media of the present invention are particularly useful for storing or archiving a series of two-dimensional black and white or color images, such as frames of a movie. Methods for reading data stored in the data storage media of the present invention using confocal microscopy are also disclosed.

  本发明涉及具有以下公式的苯乙烯染料：1其中D为电子供体基团；Q为从具有以下公式的电子受体组成的组中选择的电子受体：2W为电子受体基团；R3从取代或未取代的烷基或取代或未取代的芳基基团组成的组中选择；n为0到4的整数；A、B和C是它们的环的取代基，且每个独立地从烷基、烷氧基、羟基烷基、磺基烷基、羧基烷基和氢中选择；Y为一个计数离子。该染料和组合物表现出优越的双光子吸收截面，并可用于双光子泵浦腔激光、双光子泵浦上转换激光、光功率限制、光功率稳定、光信号重塑和红外光束检测和指示。本发明还涉及一种多相纳米结构复合材料，包括具有孔道的玻璃、孔表面上的光学活性涂层材料，例如本发明的苯乙烯染料，以及孔内的聚合物材料。可选地，聚合物材料中可以分散有第二种光学活性材料。这些复合材料可用于生产多功能光学材料，例如广泛可调谐激光器。本发明还涉及一种杀死细胞和病毒的方法。该方法包括在靠近细胞或病毒的位置提供光敏剂，例如卟啉，以及本发明的苯乙烯染料等双光子上转换染料。然后，在氧气存在的条件下，将染料暴露于光下，以对细胞或病毒产生细胞毒作用。这些方法特别适用于在生物材料中杀死肿瘤和癌症或血液净化协议等细胞和病毒。在另一方面，本发明揭示了用于记录数据的介质和方法。提供了一个三维矩阵，其中包括多个染料分子，例如本发明的苯乙烯染料分子。将矩阵中的第一个体积元素暴露于光化学辐射下，以在0.3和0.7之间改变其中所含的染料分子的分数。经过可检测的改变的染料分子在第一个体积元素中被均匀分散。本发明的数据存储方法和介质每平方厘米有大约1012个体积元素，每个体积元素可以存储一个比特、大约8个比特的数字信息或模拟信息。本发明的数据存储方法和介质特别适用于存储或归档一系列二维黑白或彩色图像，例如电影帧。还揭示了使用共聚焦显微镜读取本发明的数据存储介质中存储的数据的方法。
• Stable dye-encapsulated indium–organic framework as dual-emitting sensor for the detection of Hg²⁺/Cr₂O₇²⁻ and a wide range of nitro-compounds
  作者：Hong-Ru Fu、Ying Zhao、Tao Xie、Min-Le Han、Lu-Fang Ma、Shuang-Quan Zang

  DOI：10.1039/c8tc01571f

  日期：——

  A water-stable porous anionic metal–organic framework (MOF), [(CH₃)₂NH₂][In(TNB)_4/3]·(2DMF)(3H₂O) (1, H₃TNB = 4,4′,4′′-nitrilotribenzoicacid), was synthesized.

  一种水稳定的多孔阴离子金属有机框架（MOF），[(CH₃)₂NH₂][In(TNB)_4/3]·(2DMF)(3H₂O) (1, H₃TNB = 4,4′,4′′-nitrilotribenzoicacid)被合成。