(3,5-Dichloro-4-hydroxy-phenyl)-p-tolyl-methanone | 34183-10-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,5-Dichloro-4-hydroxy-phenyl)-p-tolyl-methanone
• 英文别名: (3,5-Dichloro-4-hydroxyphenyl)-(4-methylphenyl)methanone
• CAS: 34183-10-3
• 化学式: C₁₄H₁₀Cl₂O₂
• 分子量: 281.138
• InChiKey: WNWADQPWFOBMHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] TOLCAPONE ANALOGS AND METHODS OF USE<br/>[FR] ANALOGUES DE TOLCAPONE ET PROCÉDÉS D'UTILISATION
  申请人：[en]CORINO THERAPEUTICS, INC.

  公开号：WO2022098847A1

  公开（公告）日：2022-05-12

  Disclosed herein are compounds related to tolcapone and its metabolite, 3-OMT, along with 3-deoxytolcapone, as well as pharmaceutical compositions comprising the same. Also disclosed are methods of using such compounds and compositions, including use for the treatment or prevention of amyloid-associated diseases or disorders.