1,10-iododecanethiol | 187339-30-6

• 分子结构分类: 有机化合物 - 有机硫化合物
• 英文名称: 1,10-iododecanethiol
• 英文别名: 10-Iododecane-1-thiol
• CAS: 187339-30-6
• 化学式: C₁₀H₂₁IS
• 分子量: 300.247
• InChiKey: WZPVCOPRRNIBIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  12
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,10-iododecanethiol 在 水 、 碘 作用下， 以 六甲基磷酰三胺 、 乙醇 为溶剂， 生成 10-hydroxydecyl 11'-hydroxyundecyl 1,1'-disulfide
  参考文献：
  名称：

  Quantum Interference Effects in Self-Assembled Asymmetric Disulfide Monolayers:  Comparisons between Experiment and ab Initio/Monte Carlo Theories

  摘要：

  Electron transfer measurements between solution redox probes and a Au electrode coated with self-assembled monolayers of symmetric and asymmetric omega-hydroxyalkane disulfides are used to probe the quantum interference between hydrocarbon chains of different lengths, While nb initio theory predicts a measurable destructive interference effect between hydrocarbon chains differing in length by a single methylene unit, electron transfer rates for the ferricyanide and horse heart cytochrome c are more consistent with rates estimated in the absence of the interference effect. The discrepancy between theory and experiment is discussed in light of possible interchain electronic coupling and phase segregation within the monolayers and limitations of the theoretical models.

  DOI：

  10.1021/jp962731k
• 作为产物：
  描述：

  1,10-癸二醇 在 sodium hydroxide 、 氢碘酸 、 硫脲 作用下， 反应 3.33h， 生成 1,10-iododecanethiol
  参考文献：
  名称：

  Quantum Interference Effects in Self-Assembled Asymmetric Disulfide Monolayers:  Comparisons between Experiment and ab Initio/Monte Carlo Theories

  摘要：

  Electron transfer measurements between solution redox probes and a Au electrode coated with self-assembled monolayers of symmetric and asymmetric omega-hydroxyalkane disulfides are used to probe the quantum interference between hydrocarbon chains of different lengths, While nb initio theory predicts a measurable destructive interference effect between hydrocarbon chains differing in length by a single methylene unit, electron transfer rates for the ferricyanide and horse heart cytochrome c are more consistent with rates estimated in the absence of the interference effect. The discrepancy between theory and experiment is discussed in light of possible interchain electronic coupling and phase segregation within the monolayers and limitations of the theoretical models.

  DOI：

  10.1021/jp962731k

文献信息

• DRUG DELIVERY FROM IMPLANTS USING SELF-ASSEMBLED MONOLAYERS-THERAPEUTIC SAMS
  申请人：Agrawal C. Mauli

  公开号：US20090123516A1

  公开（公告）日：2009-05-14

  Disclosed are medical devices comprising one or more surfaces, one or more SAM molecules attached to the one or more surfaces of the medical device, and one or more therapeutic agents attached to the one or more self-assembled monolayer molecules. Also disclosed are medical devices comprising one or more surfaces, one or more self-assembled monolayer molecules attached to the one or more surfaces of the medical device, one or more linkers comprising a first functional group and a second functional group, the first functional group attached to the self-assembled monolayer molecule and a therapeutic agent attached to the second functional group. The therapeutic agent may be attached to the SAM molecule via a linker. The present invention also concerns methods of administering a therapeutic agent to a subject, comprising contacting the subject with one of the medical devices set forth herein.