| 175848-46-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• CAS: 175848-46-1
• 化学式: C₁₇H₂₀N₂O₆
• 分子量: 348.356
• InChiKey: JDDDPAJKDZJCLX-GROFFGHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.74
• 重原子数：
  25.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  97.33
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  在 三氟乙酸 作用下， 以76%的产率得到(5R,7S,8R,9R,10R)-8,9,10-Trihydroxy-7-methyl-3-phenyl-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione
  参考文献：
  名称：

  Mimics of l-rhamnose: Analogues of rhamnopyranose containing a constituent α-amino acid at the anomeric position. A rhamnopyranose analogue of hydantocidin

  摘要：

  Ionic brominative oxidation of 2-amino derivatives of protected heptonolactones derived from L-rhamnose provides a key bicyclic intermediate for the synthesis of analogues of L-rhamnopyranose with spirohydantoins and spirodiketopiperazines at the anomeric position; the same intermediate can be used for the synthesis of novel glycopeptides containing a constituent rhamnopyranose amino acid. Such materials may allow an approach to new studies of diseases induced by mycobacteria, such as tuberculosis and leprosy.

  DOI：

  10.1016/0957-4166(96)00014-6
• 作为产物：
  描述：

  1-Phenyl-3-((1R,2R,6R,7S,11S)-4,4,11-trimethyl-9-oxo-3,5,8,10-tetraoxa-tricyclo[5.2.2.0^2,6]undec-1-yl)-urea 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Mimics of l-rhamnose: Analogues of rhamnopyranose containing a constituent α-amino acid at the anomeric position. A rhamnopyranose analogue of hydantocidin

  摘要：

  Ionic brominative oxidation of 2-amino derivatives of protected heptonolactones derived from L-rhamnose provides a key bicyclic intermediate for the synthesis of analogues of L-rhamnopyranose with spirohydantoins and spirodiketopiperazines at the anomeric position; the same intermediate can be used for the synthesis of novel glycopeptides containing a constituent rhamnopyranose amino acid. Such materials may allow an approach to new studies of diseases induced by mycobacteria, such as tuberculosis and leprosy.

  DOI：

  10.1016/0957-4166(96)00014-6