(R)-(+)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)chloroacetamide | 32908-45-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (R)-(+)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)chloroacetamide
• 英文别名: (+)N-Chloracetyl-1,2,3,4-tetraidro-1-naftilamin；2-chloro-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]acetamide
• CAS: 32908-45-5
• 化学式: C₁₂H₁₄ClNO
• 分子量: 223.702
• InChiKey: SLQUITRGZWAZBX-LLVKDONJSA-N

物化性质

• 沸点：
  418.9±34.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (R)-(+)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)chloroacetamide 在 臭氧 作用下， 以 溶剂黄146 为溶剂， 生成 D-2-氨基己二酸
  参考文献：
  名称：

  Ghislandi; Vercesi, Farmaco, Edizione Scientifica, 1971, vol. 26, # 5, p. 474 - 486

  摘要：

  DOI：
• 作为产物：
  描述：

  (R)-(-)-1,2,3,4-四氢-1-萘胺 、 氯乙酰氯 在 sodium hydroxide 作用下， 以 苯 为溶剂， 生成 (R)-(+)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)chloroacetamide
  参考文献：
  名称：

  Ghislandi; Vercesi, Farmaco, Edizione Scientifica, 1971, vol. 26, # 5, p. 474 - 486

  摘要：

  DOI：

文献信息

• Amino-1,3,5-triazines N-substituted with chiral bicyclic radicals, process for their preparation, compositions thereof, and their use as herbicides and plant growth regulators
  申请人：——

  公开号：US20040157739A1

  公开（公告）日：2004-08-12

  Amino-1,3,5-triazines N-substituted with chiral bicyclic radicals, process for their preparation, compositions thereof, and their use as herbicides and plant growth regulators. The invention relates to an optically active compound of formula (I) or a salt thereof: 1 wherein the various symbols are as defined in the description, to proceses for their preparation, to compositions thereof, and to their use as herbicides or plant growth regulators. The invention also relates to novel intermediates of formula (III), (V) and (XIII) as defined in the description.

  氨基-1,3,5-三嗪经手性双环基团N-取代，其制备方法，组合物及其作为除草剂和植物生长调节剂的用途。该发明涉及化学式(I)或其盐的光学活性化合物：其中各符号如描述中定义，其制备方法，组合物及其作为除草剂或植物生长调节剂的用途。该发明还涉及描述中定义的化学式(III)、(V)和(XIII)的新中间体。
• Amino-1,3,5-triazines N-substituted with chiral bicyclic radicals, process for their preparation, compositions thereof, and their use as herbicides and plant growth regulators.
  申请人：Bayer CropScience AG

  公开号：EP2305655A2

  公开（公告）日：2011-04-06

  Amino-1,3,5-triazines N-substituted with chiral bicyclic radicals, process for their preparation, compositions thereof, and their use as herbicides and plant growth regulators. The invention relates to an optically active compound of formula (I) or a salt thereof: wherein the various symbols are as defined in the description, to proceses for their preparation, to compositions thereof, and to their use as herbicides or plant growth regulators. The invention also relates to novel intermediates of formula (III), (V) and (XIII) as defined in the description.

  N-取代手性双环基的氨基-1,3,5-三嗪、其制备工艺、其组合物及其作为除草剂和植物生长调节剂的用途。 本发明涉及一种具有光学活性的式 (I) 化合物或其盐： 其中各种符号如描述中所定义，涉及其制备工艺、其组合物及其作为除草剂或植物生长调节剂的用途。本发明还涉及如描述中所定义的式 (III)、(V) 和 (XIII) 的新型中间体。
• New fatty acid oxidation inhibitors with increased potency lacking adverse metabolic and electrophysiological properties
  作者：Dmitry O. Koltun、Timothy A. Marquart、Kevin D. Shenk、Elfatih Elzein、Yuan Li、Marie Nguyen、Suresh Kerwar、Dewan Zeng、Nancy Chu、Daniel Soohoo、Jia Hao、Victoria Y. Maydanik、David A. Lustig、Khing-Jow Ng、Heather Fraser、Jeffery A. Zablocki

  DOI：10.1016/j.bmcl.2003.09.093

  日期：2004.1

  New inhibitors of palmitoylCoA oxidation were synthesized based on a structurally novel lead, CVT-3501 (1). Investigation of structure-activity relationships was conducted with respect to potency of inhibition of cardiac mitochondrial palmitoylCoA oxidation and metabolic stability. Potent and metabolically stable analogues 33, 42, and 43 were evaluated in vitro for cytochrome P450 inhibition and potentially adverse electrophysiological effects. Compound 33 was also found to have favorable pharmacokinetic properties in rat. (C) 2003 Elsevier Ltd. All rights reserved.
• 1,2,3,4-TETRAHYDRONAPHTHALENES AND THEIR PHARAMACEUTICAL USE
  申请人：AstraZeneca AB

  公开号：EP1140852A1

  公开（公告）日：2001-10-10
• AMINO 1, 3, 5-TRIAZINES N-SUBSTITUTED WITH CHIRAL BICYCLIC RADICALS, PROCESS FOR THEIR PREPARATION, COMPOSITIONS THEREOF AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS
  申请人：Bayer CropScience GmbH

  公开号：EP1592674A1

  公开（公告）日：2005-11-09