(2E,4E)-2-(N-methylanilino)-5-phenyl-2,4-pentadienenitrile | 117873-01-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2E,4E)-2-(N-methylanilino)-5-phenyl-2,4-pentadienenitrile
• 英文别名: (2E,4E)-2-(N-methylanilino)-5-phenylpenta-2,4-dienenitrile
• CAS: 117873-01-5
• 化学式: C₁₈H₁₆N₂
• 分子量: 260.338
• InChiKey: BYTKEVBRAQAGCQ-PKNOWDFQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.24
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  27.03
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (2E,4E)-2-(N-methylanilino)-5-phenyl-2,4-pentadienenitrile 以 solid 为溶剂， 反应 6.0h， 生成 1,3-bis(N-methylanilino)-2,4-bis(2-phenylethenyl)cyclobutane-1,3-dicarbonitrile
  参考文献：
  名称：

  Solution and Solid-State Photochemistry of 2-Anilino-5-phenyl-2,4-pentadienenitriles

  摘要：

  2-(N-Methylanilino)-5-phenyl-2,4-pentadienenitrile (3) undergoes either isomerization or oxidative cleavage at the 2,3-double bond upon irradiation in solution, whereas it dimerizes in a regiospecific manner to give the [2 + 2] cycloaddition product 12 upon irradiation in the solid state. From the fluorescence spectra and semiempirical calculation, the excited state of 3 is proposed to be a twist intramolecular charge transfer species. The X-ray analysis indicates that molecules 3b orient appropriately with a reasonable distance for the [2 + 2] cycloaddition in the solid state. The distance between C2 and C3' is 525 pm, the longest distance known in solid-state [2 + 2] cycloadditions. 2-(N-Methyl-p-bromoanilino)-5-phenyl-2,4-pentadienenitrile (4) shows behavior similar to that of 3 in the solution and solid-state photochemistry, whereas analogs 7-10 having nitro substituents on the 5-phenyl rings do not dimerize upon irradiation in the solid state. Semiempirical calculation of the electronic structures is used to interprete the discrepancy of reactivity.

  DOI：

  10.1021/jo00098a037
• 作为产物：
  描述：

  2-(甲基(苯基)氨基)乙腈 在 potassium tert-butylate 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 49.08h， 生成 (2E,4E)-2-(N-methylanilino)-5-phenyl-2,4-pentadienenitrile
  参考文献：
  名称：

  2-(N-methylanilino)-2-phenylsulfanylacetonitrile, a reagent tested for electrophilic, nucleophilic and radical reactions

  摘要：

  2-(N-Methylanilino) -2-phenylsulfanylacetonitrile 1 has been readily prepared from 2-(N-methylanilino)acetonitrile and diphenyl disulfide. Alkylation of the anion of 1 with halogenoalkanes resulted in concurrent elimination of benzenethiol to give conjugated alpha-aminoalkenenitriles of 2E-configuration. Autoxidation of 1 in the presence of alkoxide ions afforded alkyl N-methyl-N-phenylcarbamates. Nucleophilic substitution of 1 with Grignard reagent or appropriate silyl compounds were promoted by Cul or Lewis acids to give varied alpha-amino nitriles. The 4-oxo-2-amino nitriles 9 obtained by condensation of 1 and titanium enolates can be considered as derivatives of 1,3-dicarbonyl compounds with the aldehyde group being activated to give an amino nitrile umpolung. When 1 was treated with tributylstannane, the corresponding amino nitrile alpha-radical was formed and the self-coupling product was isolated.

  DOI：

  10.1039/p19940002217

文献信息

• Use of .alpha.-anilino dienenitriles as nucleophiles in cycloadditions
  作者：Jim Min Fang、Chau Chen Yang、Yu Wen Wang

  DOI：10.1021/jo00263a040

  日期：1989.1