1H-吡咯啉嗪-2-胺,六氢-(9CI) | 170442-11-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯里西啶类
• 中文名称: 1H-吡咯啉嗪-2-胺,六氢-(9CI)
• 英文名称: 2-Amino-pyrrolizidin
• 英文别名: Hexahydro-1H-pyrrolizin-2-amine；2,3,5,6,7,8-hexahydro-1H-pyrrolizin-2-amine
• CAS: 170442-11-2
• 化学式: C₇H₁₄N₂
• mdl: MFCD18810374
• 分子量: 126.202
• InChiKey: DINRAJAGJMXRKY-UHFFFAOYSA-N

物化性质

• 沸点：
  168.8±8.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES<br/>[FR] DÉRIVÉS DE CYCLOHEXANE À SUBSTITUTION AMIDO
  申请人：BAYER PHARMA AG

  公开号：WO2018078009A1

  公开（公告）日：2018-05-03

  The present invention relates to amido-substituted cyclohexane compounds of general formula (I) : in which m, A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式(I)的酰胺取代的环己烷化合物，其中m、A、R4、R6、R7、R8、R9、R10和R11如本文所定义，以及制备所述化合物的方法，用于制备所述化合物的有用中间体化合物，包含所述化合物的药物组合物和组合物，以及利用所述化合物制造用于治疗或预防疾病的药物组合物，特别是肿瘤，作为唯一药剂或与其他活性成分结合使用。
• [EN] AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE<br/>[FR] DÉRIVÉS DE CYCLOHEXANE À SUBSTITUTION AMIDO EN TANT QU'INHIBITEURS DE TANKYRASE
  申请人：BAYER PHARMA AG

  公开号：WO2018087126A1

  公开（公告）日：2018-05-17

  The present invention relates to amido-substituted cyclohexane compounds of general formula (I), in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式(I)的酰胺取代环己烷化合物，其中A、R4、R6、R7、R8、R9、R10和R11如本文所定义，以及制备所述化合物的方法，用于制备所述化合物的有用中间体化合物，包含所述化合物的药物组合物和组合物，以及利用所述化合物制造用于治疗或预防疾病的药物组合物，特别是肿瘤，作为唯一药剂或与其他活性成分组合使用。
• [EN] AMIDO-SUBSTITUTED AZASPIRO DERIVATIVES AS TANKYRASE INHIBITORS<br/>[FR] DÉRIVÉS D'AZASPIRO À SUBSTITUTION AMIDO EN TANT QU'INHIBITEURS DE TANKYRASE
  申请人：BAYER PHARMA AG

  公开号：WO2018078005A1

  公开（公告）日：2018-05-03

  The present invention relates to amido-substituted cyclohexane compounds of general formula (I) : in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式(I)的酰胺取代的环己烷化合物，其中A、R4、R6、R7、R8、R9、R10和R11如本文所定义，以及制备该化合物的方法，用于制备该化合物的有用中间体化合物，含有该化合物的药物组合物和药物组合物，以及利用该化合物制造用于治疗或预防疾病，特别是肿瘤的药物组合物的用途，作为唯一药剂或与其他活性成分组合使用。