cholestene-(5)-diyl-(3β.4β)-dibenzoate | 2691-23-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: cholestene-(5)-diyl-(3β.4β)-dibenzoate
• 英文别名: Cholesten-(5)-diyl-(3β.4β)-dibenzoat；Cholest-5-en-3β,4β-diol-dibenzoat
• CAS: 2691-23-8
• 化学式: C₄₁H₅₄O₄
• 分子量: 610.877
• InChiKey: PFVQWWUVNICTBT-OLMGXZJXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.09
• 重原子数：
  45.0
• 可旋转键数：
  9.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  cholestene-(5)-diyl-(3β.4β)-dibenzoate 、 溶剂黄146 、 alkaline earth salt of/the/ methylsulfuric acid 生成 (3S,4S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,4-diyl dibenzoate
  参考文献：
  名称：

  Ultrastructural Localisation of Sialoadhesin (Siglec- 1) on Macrophages in Rodent Lymphoid Tissues

  摘要：

  In previous studies it has been demonstrated that sialoadhesin is a macrophage-restricted adhesion receptor for lymphocytes and myeloid cells. It is under normal circumstances expressed by subpopulations of macrophages in lymphoid and haemopoietic tissues. In this study different immunoelectronmicroscopical techniques are used to investigate the ultrastructural localisation of sialoadhesin within the lymph node and spleen of rodents. The results show that sialoadhesin is selectively expressed by a subset of macrophages in peripheral lymphoid tissues. Sialoadhesin was localised predominantly on the plasma membrane and in particular in areas of intimate contact with lymphocytes, thereby visualizing putative local interaction between these cells. Interestingly, sialoadhesin was also detected in intracellular vesicles that were apparently taken up by macrophages. These findings are consistent with the putative role of sialoadhesin in local cell-cell interactions in lymphoid tissues. Surprisingly, sialoadhesin was also found at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells, suggesting that sialoadhesin also mediates interactions with these cell types.

  DOI：

  10.1016/s0171-2985(00)80036-4
• 作为产物：
  描述：

  cholesterol 在 吡啶 、 selenium(IV) oxide 、 溶剂黄146 、 苯 作用下， 生成 cholestene-(5)-diyl-(3β.4β)-dibenzoate
  参考文献：
  名称：

  79.二氧化硒对固醇和胆汁酸的作用。第三部分 胆固醇

  摘要：

  DOI：

  10.1039/jr9370000377

文献信息

• Mortality and socioeconomic indicators in Spain 1962-1991
  作者：V Villanueva

  DOI：10.1093/eurpub/10.4.268

  日期：2000.12.1

  Background: The study objectives were to describe the evolution of mortality and some socioeconomic indicators in the Spanish provinces (n=50) in order to quantify their association and assess the capability of these socioeconomic factors in explaining mortality levels in the Spanish provinces over the period 1962–1991. Methods: An ecological cross-sectional study was performed in order to assess the relationships between some socioeconomic indicators and mortality in Spain. Data on both-sexes, all-causes, age-adjusted mortality and infant mortality, gross national product per head, economically active population and unemployment rates, population density, state hospital functioning beds and state primary school units were obtained at a provincial aggregation level. A convergence σ coefficient was calculated for all these indicators and simple and multiple linear regression models for mortality were fitted. Results and conclusions: The results suggested that, over the study period, mortality rates fell and socioeconomic indicators converged between provinces, but differences in mortality between provinces did not decrease. Socioeconomic factors such as unemployment or economic level - as measured through gross national product - were consistently associated with mortality over all the study period.

  背景：研究目标是描述西班牙各省 (n=50) 的死亡率和一些社会经济指标的演变，以量化其关联并评估这些社会经济因素解释西班牙各省在此期间死亡率水平的能力1962 年至 1991 年。方法：进行了一项生态横断面研究，以评估西班牙一些社会经济指标与死亡率之间的关系。有关男女、全因、年龄调整死亡率和婴儿死亡率、人均国民生产总值、经济活动人口和失业率、人口密度、公立医院功能性床位和公立小学单位的数据是在省级汇总水平上获得的。计算所有这些指标的收敛 σ 系数，并拟合死亡率的简单和多元线性回归模型。结果与结论：结果表明，在研究期间，各省间死亡率下降，社会经济指标趋同，但各省间死亡率差异并未缩小。在整个研究期间，失业或经济水平等社会经济因素（通过国民生产总值衡量）始终与死亡率相关。