2-异丙基-1,3-二恶烷-5-胺 | 760114-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 中文名称: 2-异丙基-1,3-二恶烷-5-胺
• 英文名称: trans 2-isopropyl-[1,3]dioxan-5-ylamine
• 英文别名: 2-propan-2-yl-1,3-dioxan-5-amine
• CAS: 760114-74-7
• 化学式: C₇H₁₅NO₂
• mdl: MFCD18805631
• 分子量: 145.202
• InChiKey: CHTCYGDJJDDMND-UHFFFAOYSA-N

物化性质

• 沸点：
  198.4±35.0 °C(Predicted)
• 密度：
  0.979±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pyridine derivatives inhibiting angiogenesis and/or vegf receptor tyrosine kinase
  申请人：——

  公开号：US20030158409A1

  公开（公告）日：2003-08-21

  The invention relates to pyridine derivatives of formula (I), wherein the substituents and symbols are defined as indicated in the description, processes for the preparation thereof, their usage in the preparation of a pharmaceutical composition for the treatment of a disease which responds to an inhibition of angiogenesis, and pharmaceutical compositions containing such compounds. 1

  该发明涉及式(I)的吡啶衍生物，其中取代基和符号如描述中所示定义，其制备方法，它们在制备用于治疗对血管生成抑制有反应的疾病的药物组合物中的用途，以及含有这类化合物的药物组合物。
• Pyridine derivatives inhibiting angiogenesis and/or VEGF receptor tyrosine kinase
  申请人：——

  公开号：US20040209894A1

  公开（公告）日：2004-10-21

  The invention relates to pyridine derivatives of formula (I) 1 wherein the substituents and symbols are defined as indicated in the description, processes for the preparation thereof, their usage in the preparation of a pharmaceutical composition for the treatment of a disease which responds to an inhibition of angiogenesis, and pharmaceutical compositions containing such compounds.

  本发明涉及公式（I）的吡啶衍生物，其中取代基和符号如描述中所示，其制备方法，它们在制备用于治疗对抑制血管生成有反应的疾病的药物组合物中的使用以及含有这些化合物的药物组合物。
• Phthalazine derivatives with angiogenesis inhibiting activity
  申请人：——

  公开号：US20040180899A1

  公开（公告）日：2004-09-16

  The invention relates to new phthalazine derivatives of formula (I), wherein R 1 and R 2 : a) are independently in each case a lower alkyl; b) together form a bridge of subformula (I*), wherein the bond is achieved via the two terminal C atoms and m is 0 to 4; or c) together form a bridge of subformula (I**), wherein one or two of the ring members T 1 , T 2 , T 3 and T 4 are nitrogen, and the others are in each case CH, and the bond is achieved via atoms T 1 and T 4 ; A, B, D, E and T are independently N or CH subject to the proviso that at least one and not more than three of these radicals are N; X is imino, oxa, or thia; Y is hydrogen, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or unsubstituted or substituted cycloalkyl; and wherein the bonds characterized in subformula (I*) by a wavy line are either single or double bonds; to an N-oxide of a compound of formula I; a tautomer or mixture of tautomers of a compound of formula (I) of an N-oxide thereof; and a pharmaceutically acceptable salt of a compound of formula (I), of an N-oxide or of a tautomer or mixture of tautomers thereof; processes for their preparation and pharmaceutical uses. 1

  本发明涉及公式（I）的新的邻二氮杂菲衍生物，其中R1和R2：a）各自独立地为较低的烷基；b）共同形成子公式（I *）的桥梁，其中通过两个末端C原子实现键合，并且m为0到4；或c）共同形成子公式（I **）的桥梁，其中环成员T1、T2、T3和T4中的一个或两个是氮，其余的分别为CH，并且通过原子T1和T4实现键合；A、B、D、E和T各自独立地为N或CH，但至少一个且不超过三个基团为N；X为亚胺基、氧杂基或硫杂基；Y为氢、取代或未取代的芳基、取代或未取代的杂芳基、或未取代或取代的环烷基；在子公式（I *）中由波浪线表示的键可以是单键或双键；以及公式（I）化合物的N-氧化物，公式（I）化合物的互变异构体或其N-氧化物的混合物；以及公式（I）化合物的药学上可接受的盐，其N-氧化物或其互变异构体或其混合物的制备方法和药物用途。
• Phthalazine Derivatives with Angiogenesis Inhibiting Activity
  申请人：Bold Guido

  公开号：US20090076003A1

  公开（公告）日：2009-03-19

  The invention relates to new phthalazine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof alone or in combination with one or more other pharmaceutically active compounds for the treatment of a disease, especially of a disease that responds to the inhibition of tyrosine kinases, more especially the inhibition of the vascular endothelial growth factor (VEGF) receptor kinase, preferably the treatment of a proliferative disease, such as a tumour disease.

  本发明涉及新的邻苯二酸咪唑衍生物，其制备方法，其在人或动物体内治疗过程中的应用，其单独或与一种或多种其他药物活性化合物结合使用治疗疾病，特别是对酪氨酸激酶抑制的反应疾病，更特别是对血管内皮生长因子（VEGF）受体激酶抑制的反应疾病，优选是治疗增殖性疾病，如肿瘤疾病的治疗。
• PYRIDINE DERIVATIVES INHIBITING ANGIOGENESIS AND/OR VEGF RECEPTOR TYROSINE KINASE
  申请人：Novartis AG

  公开号：EP1254138A1

  公开（公告）日：2002-11-06