5-[1-Hydroxy-2-(1-methyl-hexylamino)-ethyl]-benzene-1,3-diol | 100772-86-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-[1-Hydroxy-2-(1-methyl-hexylamino)-ethyl]-benzene-1,3-diol
• 英文别名: 5-[2-(Heptan-2-ylamino)-1-hydroxyethyl]benzene-1,3-diol
• CAS: 100772-86-9
• 化学式: C₁₅H₂₅NO₃
• 分子量: 267.368
• InChiKey: DFGXCGQPCWUBML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  72.7
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• THE USE OF FENOTEROL AND FENOTEROL ANALOGUES IN THE TREATMENT OF GLIOBLASTOMAS AND ASTROCYTOMAS
  申请人：The United States of America, as represented by The Secretary, Department of Health and Human Services

  公开号：EP2544676A1

  公开（公告）日：2013-01-16
• [EN] THE USE OF FENOTEROL AND FENOTEROL ANALOGUES IN THE TREATMENT OF GLIOBLASTOMAS AND ASTROCYTOMAS<br/>[FR] UTILISATION DU FÉNOTÉROL ET DE SES ANALOGUES DANS LE TRAITEMENT DE GLIOBLASTOMES ET D'ASTROCYTOMES
  申请人：US HEALTH

  公开号：WO2011112867A1

  公开（公告）日：2011-09-15

  This disclosure concerns the discovery of the use of fenoterol and (R, R)- and (R, S)- fenoterol analogues for the treatment of a tumor expressing a β2-adrenergic receptor, such as a primary brain tumor, including a glioblastoma or astrocytoma expressing a β2- adrenergic receptor. In one example, the method includes administering to a subject a therapeutically effective amount of fenoterol, a specific fenoterol analogue or a combination thereof to reduce one or more symptoms associated with the tumor, thereby treating the tumor in the subject.