4-(benzhydrylamino)phenol | 109810-26-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(benzhydrylamino)phenol
• 英文别名: N-<4-Hydroxy-phenyl>-benzhydrylamin
• CAS: 109810-26-6
• 化学式: C₁₉H₁₇NO
• 分子量: 275.35
• InChiKey: GVQZFLDBDVCXBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二苯甲酮亚胺 在 镍 作用下， 生成 4-(benzhydrylamino)phenol
  参考文献：
  名称：

  Cantarel; Souil, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1958, vol. 246, p. 1436

  摘要：

  DOI：

文献信息

• Photocatalytic and Chemoselective Transfer Hydrogenation of Diarylimines in Batch and Continuous Flow
  作者：Dean J. van As、Timothy U. Connell、Martin Brzozowski、Andrew D. Scully、Anastasios Polyzos

  DOI：10.1021/acs.orglett.7b03565

  日期：2018.2.16

  imines in batch and continuous flow is described. The reaction utilizes Et3N as both hydrogen source and single-electron donor, enabling the selective reduction of imines derived from diarylketimines containing other reducible functional groups including nitriles, halides, esters, and ketones. The dual role of Et3N was confirmed by fluorescence quenching measurements, transient absorption spectroscopy,

  描述了用于间歇和连续流动的亚胺化学选择性转移氢化的可见光光催化方法。该反应利用Et 3 N作为氢源和单电子供体，从而能够选择性还原衍生自含有其他可还原官能团（包括腈，卤化物，酯和酮）的二芳基酮亚胺的亚胺。Et 3 N的双重作用已通过荧光猝灭测量，瞬态吸收光谱和氘标记研究得到了证实。连续流处理有助于直接扩大反应规模。
• Copper Acetoacetonate [Cu(acac)₂]/BINAP-Promoted C<i>sp</i>³N Bond Formation<i>via</i>Reductive Coupling of<i>N</i>-Tosylhydrazones with Anilines
  作者：Jessy Aziz、Jean-Daniel Brion、Abdallah Hamze、Mouad Alami

  DOI：10.1002/adsc.201300466

  日期：2013.8.12

  AbstractWe report the the copper(II) acetoacetonate [Cu(acac)2]/BINAP‐catalyzed synthesis of arylamines from N‐tosylhydrazones and anilines. A fine tuning of the reaction conditions was required to accomplish the cross‐coupling successfully, including the ligands effect and the addition of small amounts of water. The characteristic feature of this protocol is its functional group compatibility and its chemoselectivity when various aminophenol derivatives were used. Taking into consideration the interest for this copper‐reductive coupling in which no stoichiometric metal hydride reagent is employed, this can be considered as an alternative to the conventional reductive amination.magnified image
• Correction to Photocatalytic and Chemoselective Transfer Hydrogenation of Diarylimines in Batch and Continuous Flow
  作者：Dean J. van As、Timothy U. Connell、Martin Brzozowski、Andrew D. Scully、Anastasios Polyzos

  DOI：10.1021/acs.orglett.8b02023

  日期：2018.7.20
• Cantarel; Souil, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1958, vol. 246, p. 1436
  作者：Cantarel、Souil

  DOI：——

  日期：——