4-三氟甲基吡啶-3-硫代甲酰胺 | 158063-54-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4-三氟甲基吡啶-3-硫代甲酰胺
• 英文名称: 4-(Trifluoromethyl)pyridine-3-thiocarboxamide
• 英文别名: 4-(Trifluoromethyl)pyridine-3-carbothioamide
• CAS: 158063-54-8
• 化学式: C₇H₅F₃N₂S
• mdl: MFCD00205806
• 分子量: 206.191
• InChiKey: HOPAEPDXFOSQMZ-UHFFFAOYSA-N

物化性质

• 熔点：
  153 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38

反应信息

• 作为反应物：
  描述：

  3-溴-4-氟苯甲酰甲基溴 、 4-三氟甲基吡啶-3-硫代甲酰胺 以the title compound (1.50 g) was obtained as brown needle crystals的产率得到3-[4-(3-bromo-4-fluorophenyl)-1,3-thiazol-2-yl]-4-(trifluoromethyl)pyridine
  参考文献：
  名称：

  Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof

  摘要：

  本发明提供了一种具有类固醇C17,20-裂解酶抑制活性的药物组合物，可用作前列腺增生症、乳腺癌等肿瘤的预防或治疗剂，更具体地说，是一种含有以下化合物的类固醇C17,20-裂解酶抑制剂：其中A1是一个芳香族碳氢基团，可选地具有取代基或一个杂环基团，A2和A3中的一个是氢原子、卤素原子、可选地具有取代基的C1-4脂肪烃基团或可选地酯化的羧基团，另一个是可选地具有取代基的芳香族碳氢基团或杂环基团，而A1、A2和A3中的至少一个是可选地具有取代基的3-吡啶基团，或其盐或前药。

  公开号：

  US07067537B2

文献信息

• 4-haloalkyl-3-heterocyclylpyridines, 4-haloalkyl-5-heterocyclyl-pyrimidines and 4-trifluoromethyl-3-oxadiazolylpyridines, processes for their preparation, compositions comprising them, and their use as pesticides
  申请人：——

  公开号：US20030162812A1

  公开（公告）日：2003-08-28

  The present invention relates to 4-Haloalkyl-3-heterocyclylpyridines, 4-haloalkyl-5-heterocyclyl-pyrimidines and 4-trifluoromethyl-3-oxadiazolylpyridines, Processes for Their Preparation, Compositions Comprising Them, and Their Use as Pesticides More particularly, the present invention relates to 4-trifluoromethyl-3-oxadiazolylpyridines of the formula (I′), to processes for their preparation, to compositions comprising them and to the use of these compounds for controlling animal pests, in particular insects, spider mites, ectoparasites and helminths: 1 wherein X, Y are as defined in the description.

  本发明涉及4-卤代烷基-3-杂环基吡啶、4-卤代烷基-5-杂环基嘧啶和4-三氟甲基-3-噁二唑基吡啶，以及它们的制备方法、包含它们的组合物和它们作为杀虫剂的用途。更具体地，本发明涉及式(I′)的4-三氟甲基-3-噁二唑基吡啶，其制备方法，包含它们的组合物以及这些化合物用于控制动物害虫，特别是昆虫、蜘蛛螨、外寄生虫和蠕虫的用途：其中X、Y如描述中所定义。
• NOVEL 2-HETARYLTHIAZOLE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND USE AS PHARMACEUTICALS
  申请人：Bothe Ulrich

  公开号：US20090203715A1

  公开（公告）日：2009-08-13

  The present invention relates to 2-hetarylthiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof

  本发明涉及式(I)的2-杂环基噻唑-4-甲酰胺衍生物，其用作治疗各种疾病的药物，以及其制备方法。
• 4-Haloalkyl-3-heterocyclylpyridines and 4-haloalkyl-5-heterocyclyl-pyrimidines, processes for their preparation, compositions comprising them, and their use as pesticides
  申请人：——

  公开号：US20020013326A1

  公开（公告）日：2002-01-31

  4-Haloalkyl-3-heterocyclylpyridines and 4-haloalkyl-5-heterocyclyl-pyrimidines, processes for their preparation, compositions comprising them, and their use as pesticides The present invention relates to 4-haloalkyl-3-heterocyclylpyridines and 4-haloalkyl-5-heterocyclylpyrimidines of the formula (I), to processes for their preparation, to compositions comprising them, and to the use of these compounds for controlling animal pests, in particular insects, spider mites, ectoparasites and helminths. 1 In the formula (I), Q is a 5-membered heterocyclic group which is optionally substituted by halogen or organic radicals, Y is halo-C 1 -C 6 -alkyl, X is CH or N and m is 0 or 1.

  本发明涉及式(I)的4-卤代烷基-3-杂环基吡啶和4-卤代烷基-5-杂环基嘧啶，以及它们的制备方法、包含它们的组合物，以及这些化合物作为农药控制动物害虫，特别是昆虫、蜘蛛螨、外寄生虫和寄生虫的用途。 式(I)中，Q是一个5元杂环基团，可选择地被卤素或有机基团取代，Y是卤代C1-C6-烷基，X是CH或N，m为0或1。
• Neue 2-Hetarylthiazol-4-carbonsäureamid-Derivative, deren Herstellung und Verwendung als Arzneimittel
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP2070924A1

  公开（公告）日：2009-06-17

  Die vorliegende Erfindung betrifft 2-Hetarylthiazol-4-carbonsäureamid-Derivate der Formel (I), deren Verwendung als Medikament zur Behandlung verschiedener Erkrankungen, sowie Verfahren zur deren Herstellung

  本发明涉及式（I）的 2-芳基噻唑-4-甲酰胺衍生物、其作为治疗各种疾病的药物的用途及其制备工艺
• COMPOUNDS AND COMPOSITIONS HAVING KNOCK-DOWN OR BLOOD FEED INHIBITION ACTIVITY AGAINST INSECT PESTS
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：EP3659438A1

  公开（公告）日：2020-06-03

  With the present invention it has now been found that certain 4-(trifluoromethyl)pyridine compounds and active compound compositions comprising such compounds are suitable for controlling nuisance, disease carrying or haematophagous (blood feeding) insects pests incl. dipteran, triatominae and cimicidae insect pests by knockdown or by or blood feed inhibition. In one embodiment, dipteran pests are selected from flies and mosquitoes, including insecticide-resistant flies and mosquitoes, as well as fly and mosquito vectors of pathogenic disease. Target cimicidae insect pests are selected from bed bugs. Target triatominae pests are selected from kissing bugs Other aspects of the present invention will also be apparent in the detailed description which follows.

  通过本发明，现已发现某些 4-(三氟甲基)吡啶化合物和包含此类化合物的活性化合物组合物适用于通过击倒或或抑制吸血来控制滋扰性、携带疾病或食血(吸血)昆虫害虫，包括双翅目、三齿蝇科和蜚蠊科昆虫害虫。在一个实施方案中，双翅目害虫选自苍蝇和蚊子，包括抗杀虫剂苍蝇和蚊子，以及致病性疾病的苍蝇和蚊子媒介。目标蜚蠊科害虫选自臭虫。目标三翅目害虫选自吻蝽 本发明的其他方面在下文的详细说明中也将显而易见。