N-(3,3-dimethylbutyl)-2-[2-(2,2-dimethylpropanoyl)-5-methoxy-1-benzothien-3-yl]-N-ethylacetamide | 847804-59-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,3-dimethylbutyl)-2-[2-(2,2-dimethylpropanoyl)-5-methoxy-1-benzothien-3-yl]-N-ethylacetamide
• 英文别名: N-(3,3-dimethylbutyl)-2-[2-(2,2-dimethylpropanoyl)-5-methoxy-1-benzothiophen-3-yl]-N-ethylacetamide
• CAS: 847804-59-5
• 化学式: C₂₄H₃₅NO₃S
• 分子量: 417.613
• InChiKey: HBCFXGLWHDMYSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Ophthalmic compositions for treating ocular hypertension
  申请人：Shen Dong-Ming

  公开号：US20080287489A1

  公开（公告）日：2008-11-20

  This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

  本发明涉及公式I或其制剂的强效钾通道阻滞剂化合物，用于治疗青光眼和其他导致患者眼内压升高的情况。本发明还涉及使用这些化合物为哺乳动物品种，特别是人类的眼提供神经保护作用。
• OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION
  申请人：Merck & Co., Inc.

  公开号：EP1664011A2

  公开（公告）日：2006-06-07
• EP1664011A4
  申请人：——

  公开号：EP1664011A4

  公开（公告）日：2009-02-25
• US7576122B2
  申请人：——

  公开号：US7576122B2

  公开（公告）日：2009-08-18
• [EN] OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION<br/>[FR] COMPOSITIONS OPHTALMIQUES POUR LE TRAITEMENT DE L'HYPERTENSION OCULAIRE
  申请人：MERCK & CO INC

  公开号：WO2005020917A2

  公开（公告）日：2005-03-10

  This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.